胰腺癌姑息治疗课件.pptVIP

* * 125I放射性粒子治疗胰腺癌 Clinical Analysis of 125I Seed Implantation for Pancreatic Carcinoma 吉林大学中日联谊医院 China –Japan Union hospital of Jilin University 盖保东 杨冬艳 丁大勇 马庆杰 Gai Baodong Yang Dongyan Ding Dayong Ma Qingjie 胰腺癌的手术切除率和5年生存率在过去20年中并无明显变化。局部进展期胰腺癌姑息治疗后中位生存期不超过6个月。对于更晚期胰腺癌的临床治疗就更为困难，Ⅳ期胰腺癌病人临床医生一般仅做对症治疗，病人生活质量差，生存期仅为3.0个月。 It is very difficult in treatment for advanced pancreatic cancer The survival time in those patien usually no more than 6 month For stage IV usually no more than 3 month 近年来，临床应用125I放射性粒子治疗胰腺癌，有效地提高了病人的生活质量和生存时间。 125I seed implantation for pancreatic carcinoma Quality of life St improved 外科手段治疗胰腺癌 Surgical for Pancreatic Carcinoma 1990年~2000年8省2市14家三级甲等医院 2340例胰腺癌病人临床流行病调查资料 A uniform questionnaire survey on the clinical epidemiology of pancreatic cancer was conducted by the Society of Pancreatic Cancer , Chinese Anti-cancer Association from January 1 ,1990 to December 31 ,2000 on a total of 2340 the patients with pancreatic cancer confirmed clinically or pathologically in 14 hospitals in China 目前国内可以检索到的最大宗病例报道 外科手段治疗胰腺癌 Surgical for Pancreatic Carcinoma 根治性切除489例 （20.9%） 中位生存时间为17.1个月 标准的Whipple术 保留幽门胰十二指肠切除术 胰体尾癌切除术 姑息性手术1071例（45.8％） 中位生存时间为9.0个月 胆肠旁路 胃空肠吻合术 内脏神经酒精封闭术 探查手术242例 （10.3％） 中位生存时间为4.5个月 未手术538例 （23.0％） 中位生存时间为3.0个月 O O O O Radical resection Palliative surgery Exploratory operation Nulli-surgery The median survival time 17.1m 外科手段治疗胰腺癌 Surgical for Pancreatic Carcinoma The median survival time 9.0m The median survival time 4.5m The median survival time 3.0m 手术切除率低 根治性手术肿瘤难以切除彻底 胰腺癌肿瘤生物学行为活跃、恶性度高 肿瘤局部治疗风险大、并发症多 病人生活、生存质量下降 Lower resectable rate Lower radical rate Higher malignancy grade Higher risk 外科手段治疗胰腺癌 Surgical for Pancreatic Carcinoma 粒子治疗胰腺癌 Local therapeutic pancreatic carcinoma with 125I seed implantation 寻找一种安全、有效、并发症少 病人乐于接受的局部治疗方法 放射性粒子肿瘤内植入满足 了胰腺癌局部治疗的要求 Local therapeutic pancreatic carcinoma with 125I seed implantation 精确有效: