类风湿关节炎患者血清TL1A和IL—17测定及相关因素分析.docVIP

类风湿关节炎患者血清TL1A和IL—17测定及相关因素分析 　　[摘要] 目的 通过检测类风湿关节炎（RA）患者和健康志愿者血清肿瘤坏死因子样配体1A（TL1A）和白细胞介素-17（IL-17）水平，分析其与实验室和临床指标之间的相关性，探讨其临床意义。 方法 采用双抗体酶联免疫吸附试验（ELISA）检测50例RA患者和50例健康志愿者血清TL1A和IL-17水平，分析RA患者血清TL1A及IL-17水平与炎症和临床症状之间的关系。 结果 RA患者血清TL1A和IL-17浓度分别为（1031.8±634）pg/ml和（257.07±84.88）pg/ml，明显高于健康志愿者（309.46±59.64）pg/ml和（116.12±35.31）pg/ml（P 0.05）。 结论 RA患者血清TL1A和IL-17水平明显升高，且与炎症指标及病情严重程度密切相关。 　　[关键词] 类风湿；关节炎；肿瘤坏死因子样配体1A；白细胞介素-17；肿瘤坏死因子 　　[中图分类号] R593.22 [文献标识码] A [文章编号] 1674-4721（2013）06（c）-0046-03 　　Testing of serum TL1A and IL-17 levels of rheumatoid arthritis patients and related factors analysis 　　XUE Yan1 LIN Xing1 WU Maochun1 LIU Chengliang2 WANG Changlian3 　　1.The Hospital of Fuqing City in Fujian Province， Fuqing 350300， China； 2. Kangtai Medical Laboratory of Fuqing City in Fujian Province， Fuqing 350300， China； 3.The First Affiliated Hospital of Fujian Medical University， Fuzhou 350005， China 　　[Abstract] Objectove To analysis the relationship between serum TL1A and IL-17 levels and other laboratory and clinical data by testing serum TL1A and IL-17 levels of RA patients and healthy volunteers，and evaluate the clinical significance of serum TL1A and IL-17 levels in rheumatoid arthritis （RA）. Methods 50 cases of RA patients and healthy volunteers were collected respectively， the level of serum TL1A and IL-17 was measured by enzyme-linked immunosorbent assay （ELISA）. The correlation between the level of serum TL1A， IL-17 and the data of laboratory and clinical was analyzed. Results The level of serum TL1A and IL-17[（1031.8±634） pg/ml and （257.07±84.88）pg/ml respectively）] was significantly elevated in RA patients compared with healthy volunteers[（309.46±59.64） pg/ml and（116.12±35.31） pg/ml]， the difference was statistically significant （P 0.05）. Conclusion The level of serum TL1A and IL-17 is significantly elevated in RA patients compared with healthy volunteers. There is a positive correlation between the level of serum TL1A， IL-17 and inflammatory markers as