Long-Range Periodic Patterns in Microbial Genomes Indicate 长距离的微生物基因组中周期模式显示.pptVIP

下载本文档

3
0
约4.08千字
约 21页
2018-06-24 发布于四川
举报
版权申诉

Long-Range Periodic Patterns in Microbial Genomes Indicate 长距离的微生物基因组中周期模式显示.ppt

1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
7、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Long-Range Periodic Patterns in Microbial Genomes Indicate 长距离的微生物基因组中周期模式显示

Long-Range Periodic Patterns in MicrobialGenomes Indicate Significant Multi-ScaleChromosomal Organization(Allen et. al., UCSD) presented by Suvrajit Maji Background Materials/Method Results Discussion Summary and Conclusion Background Genes in bacterial nucleoids are arranged along the long axis of the cell , to preserve the linear order of the genes along the chromosome. Wavelet analysis has been used to detect such long-range periodic patterns in inherently noisy chromosome position-dependent data Gene orientation DNA-bending profiles, and gene expression data in prokaryotes, GC/AT skew oscillations in human chromosomes were studied. Approach for Detecting Genome Position-Dependent Patterns Materials/Method Chromosome position-dependent data were analyzed for 151 prokaryotic organisms (163 chromosomes in 16 archaeal and 135 bacterial organisms): 1) GC/AT content averaged in kilobase bins, 2) gene orientation (i.e., strand), 3) fractional gene density (number or fractions of genes—per kilobase), 4) codon adaptation index (CAI) per gene. CAI measures the tendency of one of the available codons to be preferentially used for coding a specific amino acid residue. More on Wavelets … Wavelet analysis is applied to time series for which traditional methods (e.g Fourier Transform ) appear unsatisfactory. Wavelet analysis does for unsteady and/or intermittent systems what FT has done for multi-periodic systems. FT has no time resolution , not very useful on non-stationary signals. Localization in both time and frequency More on Wavelets … Descriptive Statistics for Pattern Strengths in GC/AT Content, Gene Density, and CAI across 163 Prokaryotic Chromosomes Generality of Chromosome Position-Dependent Patterns in Sequence Properties for 163 Prokaryotic Chromosomes The relative lack of patterning in gene density is a result of the low positional variability due to the short intergenic regions found in the generally gene-dense prokaryotic organis