Chapter 18 Systematic Review and Meta-analysis：18章系统回顾和荟萃分析.pptVIP

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Chapter 18 Systematic Review and Meta-analysis：18章系统回顾和荟萃分析.ppt

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Chapter 18 Systematic Review and Meta-analysis：18章系统回顾和荟萃分析

Copyright ? 2011 Wolters Kluwer Health | Lippincott Williams Wilkins Copyright ? 2011 Wolters Kluwer Health | Lippincott Williams Wilkins Chapter 18Systematic Review and Meta-Analysis Chapter Overview How to complete a systematic review. Hierarchy of evidence. Identify the domains and elements of a systematic review. Difference between narrative and systematic reviews. Identify obstacles clinicians must overcome to practice evidence-based medicine. Differences between systematic review and meta-analysis. How to conduct a meta-analysis. Concept of validity in systematic review. Role of the Cochrane Collaboration in evidence-based health care. Concept and implications of publication bias in systematic review. Systematic Review Systematic reviews are clinician friendly and summarize the evidence into a single paper—the most compelling evidence in most circumstances. Systematic review is a research process in which investigators identify previous studies that address a particular question, summarize findings, and combine data for meta-analysis. Traditional Literature Review vs. Systematic Review Systematic review: the investigators begin with an answerable question and work through a planned process. Traditional literature reviews: discuss multiple references related to an issue but often limit the included literature to that which supports the authors’ position. The Agency for Healthcare Quality and Research outlined the essential elements of systematic review. Systematic Review as a Research Process Systematic review is a research process, so the research methods impact the validity of data and conclusions drawn. Clinicians should evaluate systematic reviews carefully before accepting them at face value because of their high rankings on evidence hierarchies. A systematic review offers a comprehensive analysis of the clinical literature available at the time it’s prepared. Systematic review may lead to practice recommendations and clinical practice guidelines.