Hydrogels - Home - U of U Biomedical Engineering：水凝胶-家居- U U生物医学工程.pptVIP

Biocompatibility in Hemodialysis Significant interaction of blood Activation of humoral enzymatic pathways Activation of white blood cells and platelets Cuprophane membranes Propose a biologically inspired design? Hydrogels Definition -water insoluble, three dimensional network of polymeric chains that are crosslinked by chemical or physical bonding; -polymers capable of swelling substantially in aqueous conditions (eg hydrophilic) -polymeric network in which water is dispersed throughout the structure The Cross-links may be physical or chemical: by reaction of one or more monomers with pendant functional groups hydrogen or ionic bonding, or van der Waals interactions Hydrogels One or more highly electronegative atoms which results in charge asymmetry favoring hydrogen bonding with water; Because of their hydrophilic nature dry materials absorb water; By definition, water must constitute at least 10% of the total weight (or volume) for a materials to be a hydrogel; When the content of water exceeds 95% of the total weight (or volume), the hydrogel is said to be superabsorbant; Hydrogels: In a chemically cross-linked hydrogel, all of the polymer chains are connected by covalent bonds to form a network; and, thus Can be viewed as one one molecule of large size or supramacromolecules; The thermodynamically driven swelling force is counterbalanced by the retractive force of the crosslinked structure; The unique property of these gels is there ability to maintain their original shape during and after swelling; Two forces become equal at some point and equilibrium is reached Xerogels Dried hydrogels Usually clear and swelling in water takes a long time; The swelling behavior is due to slow diffusion of water through the compact polymer chains; A useful property in controlled drug delivery; Chitosan Applications Pharmaceutical applications monomer composition and relative amounts of multi-polymer hydrogels can be varied to alter the diffusion characteristic and