骨肿瘤靶向性壳聚糖基载药体系的分析与应用-analysis and application of chitosan-based drug delivery system targeting bone tumors.docxVIP

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骨肿瘤靶向性壳聚糖基载药体系的分析与应用-analysis and application of chitosan-based drug delivery system targeting bone tumors.docx

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骨肿瘤靶向性壳聚糖基载药体系的分析与应用-analysis and application of chitosan-based drug delivery system targeting bone tumors

重庆大学硕士学位重庆大学硕士学位论文英文摘要 PAGE PAGE VIABSTRACTBone tumors occurred in bone malignant tumors.Bone tumors often cause the patient limb disability and even life-threatening with high incidence.Chemotherapy is an essential step in the treatment of patients with bone tumors.The main role of chemotherapy is the effect of dose intensity.As the dose increased, the killing effect of chemotherapy on tumor cells will increase obviously. There is a linear relationship between chemotherapy and killing effect. Therefore, chemotherapy often bring short-acting and long-acting side effects. Sometimes have to stop taking the medication due to the serious side effects,resulting in long-term survival rates stagnating. According-ly, the development of the bone-targeting drugs, in particular the specificity of the drug transporter to the bone tissue so as to reduce in non-bone tissue distribution and binding carrier molecule, has a very important significance.Thus, Rhein can be recognized as an effective tumor active targeting agent to conjugate with CS because of its speci?c binding with the HA.In this paper,the pro-bone experiments of Rhein was assessed in bone tissue simulants. Experiments show that the affinity of Rhein amount was7.48±0.03μmol/g (n= 3),with the affinity for 60 minutes, and the pH to 6.8 and the concentration of Rhein was 7.62mg/ml. Rhein can be used as bone-targeted target head with a well affinity for the bone.In this paper, Rhein-CS was synthesized by the reaction between the activated Rhein ester and the primary amine groups of CS through the formation of amide bond. The structure of grafting Rhein was con?rmed by ultraviolet (UV) spectrophotometry, fourier transform infrared spectrometer (FT-IR) and so on. Single factor experiments show the optimum preparation conditions of Rhein-CS were that the mass ratio of Rheinester to CS was 2.3:1 and the reaction was hold at 35℃ for 10 h.MTX/Rhein-CS nanoparticles were prepared by ionic cross-linking with TPP.The optimum con