高脂大鼠脑缺血再灌注后脑组织mcp-1、nse的表达及塞来昔布的干预作用-expression of mcp - 1 and nse in brain tissue after cerebral ischemia-reperfusion in high fat rats and the intervention effect of celecoxib.docxVIP

compared (P0.05).The neurological impairment score:In control group was higher than that in the sham-operated group at every subgroup and(P0.05); hyperlipidemia group was higher than that in the control group at every subgroup (P0.05); Zea-Longa evaluation have no difference between the hyperlipidemia group and the celecoxib group except in the group of 12h, 24h reperfusion following 1h cerebral ischemia(P0.05), but have difference between the hyperlipidemia group and the celecoxib group except in the group of 48h reperfusion following 1h cerebral ischemia(P0.05).The infarction volume:Sham-operated group have no infarction area; in infarction volume appear at 1h cerebral ischemia and increased in 24h after reperfusion in the control group, the hyperlipidemia group and the celecoxib group. The infarction volume showed difference between the hyperlipidemia group and the control group (P0.05); the infarction volume showed difference between the hyperlipidemia group and the celecoxib group (P0.05).The morphological changes of cerebral tissue stained by HE:Sham-operated group had no infarction areas and evident pathological change. In control group and the hyperlipidemia group: the number of neurons at ischemic area decreased，nervecells shrank and degenerated, apparent edema be tweet tissues and vacuolization. In celecoxib group: the number of neuron which appeared degeneration and necrosis decreased, vacuolization and inter-tissue edema became relieved compared with control group.Immunohistochemical result:The expression of in MCP-1: sham-operated group have a few MCP-1 cells; the control group compared with sham-operated group, the number of MCP-1 cells was increased significantly (P0.05); compare with control group, the number of MCP-1 cells in the hyperlipidemia group was increased (P0.05); compare with hyperlipidemia group, the number of MCP-1 cells at 48h in the celecoxib group was reduced (P0.05).The expression of in NSE: sham-operated group have NSE cells; the co