凉血解毒化瘀方联中药灌肠治疗慢加急亚急性肝衰竭湿热瘀黄证临床研究.docVIP

凉血解毒化瘀方联合中药灌肠治疗慢加急亚急性肝衰竭湿热瘀黄证临床研究 　　摘要：目的 观察凉血解毒化瘀方联合中药灌肠治疗慢加急（亚急）性肝衰竭湿热瘀黄证的临床疗效。方法 将50例慢加急（亚急）性肝衰竭湿热瘀黄证患者随机分为治疗组30例和对照组20例。对照组予西医综合治疗，治疗组在此基础上予凉血解毒化瘀方口服治疗8周，并于第1周采用生理盐水结肠灌洗及大黄乌梅合剂保留灌肠。治疗开始后0、4、8、12、24周时观察2组患者丙氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、总胆红素（TBil）、血氨（NH3+）、CD3+、CD4+、CD8+、自然杀伤细胞（NK）、凝血酶原活动度（PTA）、白细胞介素（IL）、干扰素-γ（IFN-γ）变化，并进行终末期肝病模型（MELD）评分。结果 治疗开始后4周，2组患者各项指标均较基线水平明显改善，试验组TBil、IL-4、IL-6低于对照组（P中国论文网 /1/viewhtm 　　关键词：慢加急（亚急）性肝衰竭；凉血解毒化瘀方；湿热瘀黄证；临床研究 　　DOI：10.3969/j.issn.1005-5304.2016.02.011 　　中图分类号：R259.753 文献标识码：A 文章编号：1005-5304（2016）02-0037-05 　　Clinical Study on Liangxue Jiedu Huayu Formula Combined with TCM Enema in Treatment of Acute Chronic （Subacute） Liver Failure of Damp Heat and Stasis Yellow Syndrome LIU Zheng-fang1， HUANG Wei2， LI Qin1， LIN Hui1， LIU Li2 （1. Infectious Disease Hospital in Fuzhou， Fuzhou 350025， China； 2. Fujian University of Traditional Chinese Medicine， Fuzhou 350000， China） 　　Abstract： Objective To observe the clinical efficacy of Liangxue Jiedu Huayu Formula combined with TCM enema in the treatment of acute chronic （subacute） liver failure of damp heat and stasis yellow syndrome. Methods Fifty cases of acute chronic （subacute） of liver failure with damp heat and stasis yellow syndrome were randomly divided into treatment group （30 cases） and control group （20 cases）. The control group was treated with Western medicine therapy， while treatment group orally took Liangxue Jiedu Huayu Formula based on basic treatment for 8 weeks， and received normal saline colonic for lavage and Rhei Radix et Rhizoma-Mume Fructus Mixture retention for enema in the first week. ALT， AST， TBil， NH3+， CD3+， CD4+， CD8+， NK， PTA， IL and IFN-γ in the two groups were observed in the 0， 4， 8， 12， and 24 weeks after the start of treatment. Model for end-stage liver disease （MELD） score was evaluated. Results In 4-week after the start of treatment， baseline levels of all indexes were improved significantly in the two groups （P 　　基金项目：国家科技重大专项（2012ZX10005