冠脉内直接支架术与常规支架术对冠心病不稳定性心绞痛患者vwf、et和vegf影响的对比研究.pdfVIP

英 文 摘 要 consideredstatisticallysignificant. Result:(1)Therewasnosignificantdifferenceofclinical andinterventionalfeaturesbetweendirectstentinggroupand conventionalstentinggroup.(2)Beforestenting,thedifferences ofthelevelsofvWF,ET,VEGFwerenotsignificantbetween thetwogroups(p0.05);ThelevelsofvWF.ETandVEGF afterprocedureweresignificantlyhigherthanthosebefore procedure;post-proceduralpeaklevelsofvWF、ETandVEGF wereat4hours,12hoursand7daysrespectivelyinthetwo groups,furthermore,post-proceduralpeaklevelsofvWF,ET andVEGFinconventionalstentinggroupwerehigherthan thoseindirectstentinggroup(p0.05).(3)Restenosisoccurred in 19.8%(19/96)ofpatients,ofwhich 73.7(14/19)with recurrenceofischemia.19patientsoccurredrestenosis.The incidenceofrestenosisinconventionalstentinggroupwas higherthanthoseindirectstentinggroup(p0.05).(4)The post-proceduralpeaklevelsofvWF(relativeriskRR=3.841， confidenceinternalCI=2.086-5.230,P=0.008)、ET(RR=2.457, CI=1.633-4.206,p=0.013),VEGF(RR=2.531，CI=1.682-4.035, P=0.010).PTCA+stent(RR=1.578,CI=1.235-2.116.P=0.035) andstentlength(RR=1.276,CI=1.083一1.986,P=0.028)werethe independentpredictorsofrestenosis.(5)Therewerepositive correlationsbetweenpeaklevelsofvWFandET(r=0.7361，P =0.0001)，andalsobetweenpeaklevelsofETandVEGF (r=0.6811，P=0.0001). Conclusions:Directstentimplantionproducelighter 英 文 摘 要 vesselwallinjury,andlesseffectsonvWF,ETandVEGFand lowerincidenceofrestenosis,inthefitfulrangeofcoronary lession stenting ，thedirectstentingisbetterthanconventional Keywords:percutaneouscoronaryintervention(PCI); stenting;vWF;ET;VEGF;restenosis 研 究 论 文 冠脉内直接支架术与常规支架术对冠心病不 稳定性心绞痛患者AF,ET和VEGF影响的对比研究 前 言 冠状动脉内支架治疗已成为冠心病介入治疗领域的一 种主要技术，支架置入术己于 1987年开始运用于临床。通 过支架支撑、扩张管腔，防止血管弹性回缩和痉挛，封闭撕 裂的内膜和夹层，防止血管重构，有效