实脾饮对糖尿病肾病脾肾阳虚证大鼠模型tc、tg及肾脏组织学的实验分析-experimental analysis of shi pi yin on tc, tg and renal histology in diabetic nephropathy rats with spleen-kidney yang deficiency syndrome.docxVIP

实脾 实脾饮治疗糖尿病肾病脾肾阳虚证的实验研究 PAGE PAGE 36 ABSTRACT Objective: Experimental Study of Shi Pi Yin the effectiveness of the treatment of diabetic nephropathy Shi Pi Yin deficiency syndrome and explore its mechanism， observation Shi Pi Yin the treatment of diabetic nephropathy and its related indicators. Provide a scientificsis for the revention and treatment of diabetic nephropathy and drug. Methods: the first experimental high-fat diet-induced， and then using the classic rat small dose streptozotocin Zuo streptozotocin (STZ) modeling method ， the production of diabetic nephropathy rat model， combined with traditional Chinese medicine syndrome etiology， the use of adenine pluscold medication mixed gavage. Rats if the symptoms of eating less， tail cold， hair lose their luster， unresponsive， arched back and curled up， fatigue，listlessness，etc.，for Pi Shen Yang Xu syndrome of diabetic nephropathy model was successful，and then removed the model unsuccessfulmouse，the rat model by weight， numbered according to the random number table is divided into five groups：Model control group， benazepril group， Shi Pi Yin high–dose group， Shi Pi Yin middle–dose group， Shi Pi Yin low–dose group. Observe blood glucose, serum creatinine, blood urea nitrogen, triglycerides, cholesterol, 24-hour urinary protein excretion, body weight, kidney index given real Shi Pi Yin， proteinuria and renal function， renal pathological changes， and then observe the the Shi Pi Yin the treatment of diabetic nephropathy spleen deficiency syndrome. Results: Shi Pi Yin can significantly improve diabetic nephropathy polydipsia ， polyphagia and weight loss symptoms， lower urinary protein， triglycerides and cholesterol. Improve renal function， and reduce the pathological changes of the kidney. Conclusion: Shi Pi Yin can lower the blood sugar of diabetic nephropathy in rats, triglycerides, blood urea nitrogen, 24-hour urine protein. Also increase the experimental body weight of rats improve kidney weight /