从兴奋收缩耦联机制看心力衰竭正性肌力药物发展ppt课件.pptVIP

从兴奋收缩耦联机制看心力衰竭正性肌力药物发展;提 要;兴奋-收缩耦联机制;;Excitation-contraction (EC) coupling is a term coined in 1952 to describe the physiological process of converting an electrical stimulus to mechanical response. ;Cardiac excitation–contraction coupling is the process from electrical excitation of the myocyte to contraction of the heart (which propels blood out). The ubiquitous second messenger Ca2+ is essential in cardiac electrical activity and is the direct activator of the myofilaments, which cause contraction. ;Cardiac tissue; Cardiac cells;The action potential moves through sarcolemma;Ca2+- induced