通过观察et bgp指标变化研究通络补肾法治疗激素性股骨头缺血性坏死-study on treatment of steroid-induced avascular necrosis of femoral head by dredging collaterals and tonifying kidney by observing changes of et bgp index.docxVIP

成都中医药大学 成都中医药大学 2013 届硕士研究生学位论文 PAGE PAGE 3 Abstract Purpose: By observing the changes of ET and BGP research the method of Tong Luo Bu Shen treating steroid-induced avascular necrosis of femoral head, for the method of Tong Luo Bu Shen treating steroid-induced avascular necrosis of femoral head provides the theory basis. Methods: 96 of Japanese big ear rabbits were randomly divided into normal group (24) and module (72), after the completion of the building, each group of randomly selected 8 only, to test whether building success, made after the success of the mould and then build modules were randomly divided into Huo Xue Tong Luo Tang high dose group, middle dose group, low dose group and model group. According to He Xijing made molding mould, according to the high, medium and low dose treatment group respectively, filling and invigorate the Huo Xue Tong Luo Tang; model group and normal group were filling amount of distilled water. In 6 weeks, 8 weeks after the treatment of plasma ET, BGP and BGP related data detection and analysis of the femoral head at the same time observe the trabecular bone of the pathological slices of the femoral head, the trabecular bone of the bone cells, empty pit of bone, bone marrow hematopoietic cells, fat cells, and electron microscopy observation of femoral head empty bone lacunae, strives for the empty rate of the bone pit. Results: 6 weeks after the treatment: compared with normal group, model group increased (P0.05), plasma ET content serum BGP content, femoral head BGP immunohistochemical IOD values significantly decreased (P0.01), the bone lacunae femoral head empty rate increased significantly (P0.01); Compared with model group, high, medium and low dose group of plasma ET content decreased (P0.05), serum BGP content, femoral head BGP immunohistochemical IOD values increased (P0.05), bone lacunae femoral head empty rate is lower (P0.05); Comparison between high, medium and low dose group significant difference (P0.05). 8