稳定hbv感染及肝硬化重叠hev的临床特征及il-22水平研究-study on clinical characteristics and il - 22 level of stable hbv infection and liver cirrhosis overlapping hev.docxVIP

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稳定hbv感染及肝硬化重叠hev的临床特征及il-22水平研究-study on clinical characteristics and il - 22 level of stable hbv infection and liver cirrhosis overlapping hev.docx

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稳定hbv感染及肝硬化重叠hev的临床特征及il-22水平研究-study on clinical characteristics and il - 22 level of stable hbv infection and liver cirrhosis overlapping hev

第三军医大学硕士学位论文第三军医大学硕士学位论文万方数据万方数据 mM MELD nt NUCs millimol model of end-stage liver disease nucleotide nucleoside analogues 毫摩尔终末期肝病模型核苷酸核苷类似物 OD optical density 吸光度 OR odds ratio 比值比 PCR PTA PLT s SBP TBIL Th TNF-α WBC μL polymerase chain reaction prothrombin activity platelet second spontaneous bacterial peritonitis total bilirubin T helper cell tumor necrosis factor-α white blood cell microliter 聚合酶链反应凝血酶原活动度血小板秒自发性细菌性腹膜炎总胆红素辅助性 T 细胞肿瘤坏死因子 α 白细胞微升 2 The research of clinical characters and serum levels of IL-22 in stable states of chronic HBV infection and cirrhosis overlapping with acute HEV infection ABSTRACT Hepatitis E Virus (HEV) infection may cause acute inflammation of liver. The disease is mostly self-limited, and most patients can be cured without treatment. However, for the elderly, pregnant women and patients with initial liver diseases, HEV infection can acutely worsen their condition, leading to acute decompensation of liver function and even liver failure with poor prognosis. Chronic hepatitis B virus (HBV) infection is very common in China, and its overlapping with acute hepatitis E (AHE) causes severe illness and severe economic and health burden. The natural history of chronic HBV infection contains two stable states: immune tolerance and inactive carrier. Immune tolerance is featured by positive serum HBeAg, and high-level replication of HBV ( ＞ 105IU/mL) without inflammatory of liver. Inactive carrier is featured by negative HBeAg. In this state, HBV is lower than lower limit of detection, and the inflammatory activity is absent. At present, few researches focus on the effect of overlapping acute HEV infection in stable state of chronic HBV infection on the progression of liver diseases and HBV replication. Meanwhile, due to prolonged HBV infection, chronic liver injury and tissue fibrosis progress alternately, and the annual and cumulative incidence rates of cirrhosis of patients with chroni