β七叶皂甙钠对脑出血急性期疗效观察.docVIP

β七叶皂甙钠对脑出血急性期疗效观察 　　【摘要】 目的 观察β-七叶皂甙钠治疗脑出血急性期疗效及头颅CT的改善。方法 选择经CT确诊的急性脑出血患者94例,随机分两组。治疗组50例给予β-七叶皂甙钠20 mg/d,酌情给予甘露醇50~75 g/d静脉滴注。对照组44例给予甘露醇100~200 g/d静脉滴注。10 d 1疗程,观察2疗程。结果 治疗组总显效率64%,总有效率86%;对照组总显效率40.9%,总有效率65.9%。两组比较差异有统计学意义(P0.05)。结论 β-七叶皂甙钠治疗急性脑出血临床疗效显著。 　　【关键词】β-七叶皂甙钠;急性脑出血;脑水肿 　　 　　The observation on therapeutic effect of β-sodium aescinate on acute intracerebral hemorrhage 　　 　　WANG Jianjun,OU Jian-gang,ZOU Da-liang,et al.Department of Neurology,Chenxinghai Hospital of Zhongshan,528415,Guangdong,China 　　 　　【Abstract】 Objective To observee the therapeutic effect of β-sodium aescinate on acute brain edema and the the change of head CT.Methods 94 patients were confirmed by head CT and divided into two groups in randomly.The therapeutic group(50 cases)were treated by β-sodium aescinate(20 mg/d)and Mannitol(50-70 g/d)according to the condition.The control group(44 cases)were treated by Mannitol(100-200 g/d).Ten days were one period and there were two period.Results In the therapeutic group,the summed apparently efficiency is 64%,the summed efficiency is 86%.In thecontrol group,the summed apparently efficiency is 40.9%,the summed efficiency is 65.9%.There are singnificant differences between the two groups(P0.05).Conclusion β-sodium aescinate has a significant therapeutic effect on acute brain edema 　　【Key words】β-sodium aescinate; Acute intracerebral hemorrhage; Brain edema 　　 　　作者单位: 528415广东省中山市陈星海医院神经内科 　　 　　 　　β-七叶皂甙钠是七叶树科植物提取物,具有有效的抗渗出、消肿胀作用,广泛应用于各种原因引起的炎症、脑水肿与静脉回流障碍等疾病。我院于2006年10月至2009年10月用β-七叶皂甙钠对46例脑出血急性期患者临床疗效及头颅CT改变观察,与对照组比较,效果明显。现报告如下。 　　1 资料和方法 　　1.1 一般资料 入院患者随机分组,治疗组50例,男26例,女24例,年龄44~69岁,平均(56.6±12.5)岁;脑动脉硬化38例,高脂血症19例,高血压性心脏病23例;头颅CT: 内囊区出血30例,基底神经节出血7例,脑叶、桥脑出血8例,小脑出血5例。半球出血量8~28 ml,平均为(17±11)ml、桥脑、小脑出血量为6~12 ml。对照组44例,男25例,女19例,年龄46~71岁,平均(57.5±11.5)岁;脑动脉硬化35例,高脂血症16例,高血压性心脏病19例,头颅CT:内囊区出血22例,基底神经节出血10例,脑叶、桥脑出血8例,小脑出血4例。半球出血量9~28 ml,平均(18±10)ml、桥脑、小脑出血量为8~13 ml。凡幕上出血超过30 ml,幕下出血超过15 ml,行颅内血肿微创清除术者未列入,所有病例血压210~160/120~100 mm Hg。两组