NLR在AECOPD合并肺动脉高压患者中临床意义.docVIP

NLR在AECOPD合并肺动脉高压患者中临床意义 　　【摘要】 目的：探?中性粒细胞/淋巴细胞比值（NLR）在评估慢性阻塞性肺疾病急性加重期（AECOPD）合并肺动脉高压患者病情严重程度中的价值。方法：选取2014年9月-2016年12月于甘肃省人民医院呼吸科就诊的AECOPD患者78例、COPD稳定期患者23例。根据肺动脉压力将AECOPD患者分为AECOPD组合并肺动脉高压组47例（A组）、单纯AECOPD组31例（B组）；COPD稳定期患者为C组。同时将A组细分为合并轻度肺动脉高压组14例（A1组）、中度肺动脉高压组18例（A2组）以及重度肺动脉高压组15例（A3组）。比较A、B、C组间NLR、PaO2、PaCO2的差异，比较A1、A2、A3组间NLR、PaO2、PaCO2水平的差异，并分析NLR水平与肺动脉压、PaO2、PaCO2的相关性。结果：A组NLR、PaCO2水平均明显高于B、C组，B组NLR、PaCO2水平均高于C组，比较差异均有统计学意义（P0.05）。AECOPD合并肺动脉高压患者NLR水平随着肺动脉压力的增加而增高，NLR水平与肺动脉压、PaCO2呈正相关（r=0.589，0.682），与PaO2呈负相关（r=-0.447）。结论：NLR可成为反映AECOPD合并肺动脉高压患者病情严重程度的重要指标，NLR水平有助于判断患者病情的变化。 　　【关键词】 中性粒细胞/淋巴细胞比值； 慢性阻塞性肺疾病急性加重期； 肺动脉高压 　　【Abstract】 Objective：To evaluate the value of neutrophil to lymphocyte ratio（NLR）in assessing the severity of AECOPD in patients with pulmonary hypertension.Method：78 cases of AECOPD and 23 cases of COPD stable were treated in department of respiration of Gansu Provincial People’s Hospital from September 2014 to December 2016.According to the level of pulmonary artery pressure，the patients of AECOPD were divided into pulmonary hypertension group of 47 cases（group A） and AECOPD group of 31 cases（group B），23 cases of stable COPD was group C.At the same time，group A was divided into AECOPD with mild pulmonary hypertension group were 14 cases（group A1），AECOPD with moderate pulmonary hypertension group were 18 cases（group A2） and AECOPD complicated with severe pulmonary hypertension were 15 cases（group A3）.The differences of NLR，PaO2 and PaCO2 between A，B and C group were compared，and the differences of NLR，PaO2 and PaCO2 levels between A1，A2，A3 group were compared，correlation between NLR level and pulmonary artery pressure，PaO2 and PaCO2 was analyzed.Result：NLR and PaCO2 level of group A were significantly higher than those of group B and group C，NLR and PaCO2 level of group B were higher than those of group C，the difference were statistically significant（P0.05）.The level of NLR in patients with AECOPD complicated with pulmonary hypertension w