SurvivinNRP1在胃癌中表达及其对胃癌预后影响.docVIP

SurvivinNRP1在胃癌中表达及其对胃癌预后影响 　　[摘要] 目的 探讨存活素（Survivin）、神经纤维网蛋白1（NRP1）在胃癌中的表达及其对胃癌预后的影响。 方法 应用免疫组化法测定60例胃癌组织及60例正常胃黏膜组织中Survivin、NRP1表达情况，应用Kaplan-Meier计算Survivin阳性、NRP1阳性患者5年生存率，以Cox风险模型分析影响胃癌患者预后的危险因素。 结果 胃癌组织中Survivin阳性表达率为86.67%，NRP1阳性表达率为83.33%，而在胃正常黏膜组织中的表达分别为6.67%、5.00%，差异有统计学意义（P0.05）。Survivin阳性表达率与TNM分期、累及浆膜层、浸润深度、淋巴结转移有关（P0.05）。NRP1阳性表达率与TNM分期、浸润深度及淋巴结转移有关（P0.05）。60例胃癌患者术后随访5年，共56例获得随访，5年存活为25例，5年存活率为44.64%，其中Survivin阳性存活率35.42%（17/56），NRP1阳性存活率为32.61%（15/56）。经Cox风险分析可知，Survivin阳性、NRP1阳性是影响胃癌预后的独立危险因素。 结论Survivin、NRP1可能与胃癌发生及进展相关。Survivin、NRP1表达状态是胃癌预后的独立预测因素，其阳性表达可提示患者预后不良。 　　[关键词] 存活素；神经纤维网蛋白；胃癌；预后 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1673-9701（2016）25-0008-04 　　The impact of Survivin， NRP1 in gastric cancer and its prognosis of gastric cancer 　　ZHANG Yiming ZHAO Maosen ZHU Renwu GU Yechun 　　Department of General Surgery， Wenzhou Hospital of Interated Traditional Chinese and Werstern Medicine in Zhejiang Province， Wenzhou 325001， China 　　[Abstract] Objective To investigate the expression of Survivin， nerve fiber web protein 1（NRP1）in gastric and its impact on the prognosis of gastric. Methods The Survivin， NRP1 of 60 cases of gastric cancer and 60 cases of normal gastric mucosa were detected with immunohistochemistry method. The 5-year survival rate of Survivin positive， NRP1 positive were applicated with Kaplan-Meier.The risk factors of patients with gastric cancer were analyzed with Cox hazard regression model. Results Survivin expression in gastric cancer was 86.67%， NRP1 positive rate was 83.33%， while expression in normal gastric mucosa were 6.67%， 5.00%（P0.05）. Survivin expression rate was related with TNM stage， involving the serosa， depth of invasion and lymph node metastasis（P0.05）. NRP1 positive expression rate was related with TNM stage， depth of invasion and lymph node metastasis（P0.05）. 60 gastric cancer patients were followed up for 5 years， 56 patients were followed up， 5-year survival of 25 cases， 5-year survival rate was 44.64%， which