TNF拨梁Neuritin在四肢骨折合并脊髓损伤患者血清中表达变化及临床意义.docVIP

TNF拨梁Neuritin在四肢骨折合并脊髓损伤患者血清中表达变化及临床意义 　　【摘要】目的探讨血清肿瘤坏死因子α（TNFα）和神经突起因子（Neuritin）水平在四肢骨折伴脊髓损伤中对骨折愈合的作用。方法选择2016年5月～2017年4月收治的42例单纯骨折患者（单纯骨折组）、26例单纯脊髓损伤患者（单纯脊髓损伤组）、30例四肢骨折合并脊髓损伤患者（四肢骨折合并脊髓损伤组）；同期选取48例在体检中心行健康体检的正常人（正常组）。采用酶联免疫吸附（ELISA）技术检测血清TNFα和Neuritin水平在各病例组术后第3、7、14天的变化情况，同时检测其在正常?M中的表达水平。结果术后不同时间段，单纯骨折组、单纯脊髓损伤组、四肢骨折合并脊髓损伤组血清TNFα、Neuritin含量呈动态表达现象，且均高于正常组，其中以四肢骨折合并脊髓损伤组变化最大，其TNFα、Neuritin变化幅度明显高于其他三组，差异有统计学意义（P0.01）。结论四肢骨折合并脊髓损伤患者外周血中TNFα与Neuritin含量变化情况明显高于其余三组，表明与创伤骨折的修复存在密切关联，这两种因子可能在骨折愈合过程中共同发挥作用，故推断其可能是脊髓损伤后加速骨折愈合的关键因子。 　　【关键词】肿瘤坏死因子α；神经突起因子；脊髓损伤；骨折愈合 　　中图分类号：R683.4；R651.2文献标识码：ADOI：10.3969/j.issn2018.02.004 　　Change of expression of TNFα and Neuritin in the serum of patients with 　　extremities fracture with spinal cord injury and its clinical significance 　　LIAO Linbo1，LAN Changgong2，PENG Weibo2，TANG Yujin2， 　　XIE Kegong2，LIANG Junqing1，WU Zhaoyuan1，LI Wei1 　　（1.Graduate School，2.Department of Spinal Osteopathy Surgery of Affiliated Hospital，3.Department of Traumatic 　　Orthopedics of Affiliated Hospital，Youjiang Medical University for Nationalities，Baise 533000，China） 　　【Abstract】ObjectiveTo investigate the role of serum tumor necrosis factorα （TNFα） and neurite factor （Neuritin） in the healing of extremities fracture with spinal cord injury.MethodsFrom May 2016 to April 2017，42 patients with simple fractures（simple fracture group），26 patients with simple spinal cord injury （simple spinal cord injury group），and 30 patients with extremities fracture with spinal cord injury （extremities fracture with spinal cord injury group） were selected for this study.During the same period，48 normal persons who underwent physical examination in physical examination center were also selected（normal group）.The levels of serum TNFα and Neuritin were detected by immunoassay （ELISA） on the 3rd，7th and 14th day after operation in each case group，and their expression levels in the normal group were detected at the same time.ResultsAt different time after oper