IVFET周期中控制性超促排卵对阴道微生态影响.docVIP

IVFET周期中控制性超促排卵对阴道微生态影响 　　【摘 要】 目的:了解IVF-ET周期中控制性超促排卵（COH）对阴道微生态的影响。方法：选取2010年4月~2010年10月在北京大学第一医院生殖与遗传中心接受GnRHa-长方案降调节IVF-ET治疗的患者100例，在COH前检查阴道微生态，在HCG注射日再次检查阴道微生态情况，两次结果进行自身对照研究。结果：100例患者中，COH前有微生态失调者13例，其中BV 2例（2%）,菌群正常功能下降9例（9%），菌群异常2例（2%）。COH后，菌群失调者42例（42％），其中VVC 9例（9%），BV 6例（6%），BV中间型3例（3%），菌群正常功能下降15例(15%)，菌群异常9例（9%）,有统计学差异（P0.05）。87例COH前检查阴道微生态正常者中，COH后34例发生微生态失调（39.9％）。13例COH前检查阴道微生态失调者中，COH后8例发生微生态失调（61.5％），有统计学差异（P0.05）。结论：接受COH治疗的患者容易发生阴道微生态失调，COH前已经有阴道微生态异常的患者更容易发生微生态失调，建议在进行COH治疗前和取卵手术前进行阴道微生态检查，对BV和VVC患者取卵前采取药物治疗，阴道菌群异常和功能下降患者要密切观察。 　　【关键词】 阴道微生态； 体外受精-胚胎移植； 控制性超促排卵； 微生态失调； 阴道菌群； 辅助生殖技术 　　 　　Influence of controlled ovarian hyperstimulation (COH) on vaginal microflora during IVF-ET cycles 　　ZHANG Lei, CHEN Fei, XU Yang, et al. 　　Center of Genetics and Reproduction, The First Hospital of Peking University, Beijing 100034, China 　　【Abstract】 Objectives: To understand the influence of controlled ovarian hyperstimulation on vaginal microflora during IVF-ET cycles. Methods: One hundred patients were selected who underwent GnRHa-long protocol IVF-ET treatment in Peking University First Hospital from April, 2010 to October, 2010. Vaginal microflora was tested and compared before COH and on the day of HCG injection. Results: The test on the 100 patients before COH revealed 13 patients with microflora dysbiosis, including 2 BV (2%), 9 patients with decreased function but normal microflora (9%), 2 patients with abnormal microflora (2%). After COH, 42 patients had microflora dysbateriosis, including 9 VVC (9%), 6 BV (6%), 3 intermediate BV (3%), 15 decreased function with normal microflora (15%), 9 abnormal microflora (9%). The difference is statistically significant (p0.05). Among the 87 patients with normal vaginal microecology before COH, 34 had microflora dysbiosis after COH (39.9%). Among the 13 patients who had vaginal microflora dysbiosis, 8 had microfloral dysbiosis after COH (61.5%). The difference is statistically significant (p0.05). Conclusion