VEGFc―erbB―2与NSCLC血管生成及淋巴道转移相关性研究.docVIP

VEGFc―erbB―2与NSCLC血管生成及淋巴道转移相关性研究 　　[摘要] 目的 探讨VEGF、c-erbB-2与NSCLC血管生成及淋巴道转移的相关性。方法 方便选取聊城市中医院2004―2012年非小细胞肺癌存档蜡块54例作为观察组，对照组选择20例肺良性病变手术切除标本，观察两组的VEGF、c-erbB-2水平。结果 54例非小细胞肺癌组织病理切片中，C-erbB-2阳性表达40例，阴性表达14例，阳性表达率达74.07%，两者比较有显著差异（P0.05）。54例非小细胞肺癌肺癌组织病理切片中，VEGF阳性表达36例，阴性18例，阳性表达率为66.67%，肺良性病变中，VEGF阳性2例，阴性18例，阳性表达率为10%，两者比较有显著生物学差异。结论 VEGF、c-erbB-2与非小细胞肺癌的发生发展中密切相关，并在此过程中起到一定的调控作用， VEGF、c-erbB-2表达增强预示着患者较易发生淋巴结转移，提示患者预后不佳，有助于早期判断预后。 　　[关键词] VEGF；c-erbB-2；NSCLC；血管生成；淋巴道转移 　　[中图分类号] R737.9 [文献标识码] A [文章编号] 1674-0742（2016）05（a）-0053-03 　　[Abstract] Objective To discuss the correlation between VEGF， c-erbB-2 and NSCLC angiogenesis and lymphatic metastasis. Methods 54 cases of stored paraffin blocks of non-small cell lung cancer from 2004 to 2012 were regarded as the observation group， 20 cases of surgical excision specimens of benign pulmonary lesions were selected as the control group， and the VEGF and c-erbB-2 levels of the two groups were observed. Results In the 54 cases of pathologic tissue slices of non-small cell lung cancer， the positive expression of C-erbB-2 was in 40 cases and the negative expression of C-erbB-2 was in 14 cases， and the positive expression rate was 74.07%， and there was an obvious difference between the two by comparison（P0.05）， the positive expression of VEGF was in 36 cases and negative expression of VEGF was in 18 cases， and the positive expression rate was 66.67%， in the benign pulmonary lesions， positive VEGF was in 2 cases， negative VEGF was in 18 cases， and the positive expression rate was 10%， and there was an obvious biological difference between the two by comparison. Conclusion VEGF and c-erbB-2 are closely related to the occurrence and development of non-small cell lung cancer and play a certain regulation role in this process， and the expression intensity of VEGF and c-erbB-2 indicates that lymphatic metastasis easily occurs to patients and reminds poor prognoses of patients， which is conducive to the early judgment of prognos