VEGFR2基因SNPA18487T与HiHiLo后定量负荷下SpO2变化关联研究.docVIP

VEGFR2基因SNPA18487T与HiHiLo后定量负荷下SpO2变化关联研究 　　摘 要: 目的:探讨VEGFR2(血管内皮生长因子受体2)基因SNP/A+18487T多态性与HiHiLo后 定量负荷下SpO2变化的关联性。方法:选取71名中国北方平原地区汉族男子进行30 d高住 高练低训(HiHiLo),方案为每日在低氧房(O2浓度为14.8%～14.3%,海拔约2 800～3000m)居住10 h,每周进行3次75% VO2max强度的低氧训练(O2浓度为15.4%～14.8%,海 拔约2 500～2 800 m),运动时间为30 mim/次,其余时间在常氧环境下训练。使用脉搏血 氧饱和度测试仪测试HiHiLo前后定量负荷下SpO2。采用PCR?RFLP法分析VEGFR2基因A+184 87T单核苷酸多态性。结果:VEGFR2基因A+18487T多态性与低氧训练后定量负荷运动下SpO2变化有关联。其中AA基因型者SpO2升高幅度显著大于其他基因型者。结论:AA基因型者 在低氧训练后产生了较好的低氧适应,可以作为预测低氧训练后定量负荷运动下SpO2变化 的分子遗传学标记。 　　关键词:血管内皮生长因子受体2;基因多态性;低氧训练;血氧饱和度 　　中图分类号:G804.7 　　文献标识码:A 　　文章编号 :1007-3612(2010)02-0049-04 　　The Correlation between the VEGFR2 Gene A+18487T Polymorphism an d Changes of SpO2 after HiHiLo 　　NIE Jing?1,HU Yang?2,YI Long?yan?2,WANG Jing?ling?2,ZHA NG Li?3 　　(1.Jiangxi Normal University, Nanchang 330022,Jiangxi China;2. Beijing Sport University, Beijing 100084, China;?3. China Institute of S port Science, Beijing 100061, China) 　　Abstract: The thesis is to explore the correlation between VEGFR2 gene A+18487T polymorphism and the changes of SpO2 after hypoxic training by doing HiHiLo tr aining for 71 men of Han nationality in northern China for 30 days. The Training programme is carried out as follows: being exposed in hypoxic environment (14.8 %～14.3%O2,10h/day), three times hypoxic training per week (15.4%～14.8%O2),and in the other time, trained at sea level. SpO2 were monitored before and a fter HiHiLo. The genotype was analyzed by PCR?RFLP. It is found that there is a correlation between VEGFR2 gene polymorphism and the changes of SpO2 after 4 ?W hypoxic training. The AA genotype of SNP/A+18487T in VEGFR2 gene increased s ignificantly in SpO2 after HiHiLo. In conclusion, Men carrying AA probably hav e the better ability of adapting to hypoxia than those carrying AT and TT. There fore, the polymorphysim is the genetic marker for the response of SpO2 to hypoxi c training. 　　Key words: VEGFR2;gene polymorphism;hypoxic training;SpO2 　　 　　低氧训练作为提高有氧耐力素质的手段之一,已被国内外体育