MP感染和小儿支气管哮喘相关性研究.docVIP

MP感染和小儿支气管哮喘相关性研究 　　[摘要] 目的 探讨肺炎支原体（MP）感染与小儿支气管哮喘的关系。方法 采用回顾性分析方法，方便选取2014年2月―2016年12月在该院治疗的小儿支气管哮喘90例（哮喘组），同时选取呼吸道感染患儿100例作为对照组，检测各患儿血清MP抗体、血清嗜酸性粒细胞（EOS）、第 1 秒用力呼气容积占预计值百分比（FEV1%pred）水平以及最大呼气峰流量占预计值百分比（PEF%pred）水平。结果 哮喘组MP检测阳性率为46.67%，明显高于对照组（P0.05）；哮喘组MP阳性患儿血清EOS为（620.02±56.92）×106/L，明显高于MP阴性患儿（P0.05），而FEV1%pred为（64.81±8.83）%，PEF%pred为（63.76±9.86）%，明显低于MP阴性患儿（P0.05）。结论MP感染与小儿支气管哮喘有一定关系，且可影?患儿血清EOS水平， MP在哮喘的急性发作期感染率较高。 　　[关键词] 肺炎支原体；支气管哮喘；小儿 　　[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2017）09（c）-0008-03 　　Research on Correlation between the MP Infection and Children with Bronchial Asthma 　　FAN Min-hao 　　Department of Pediatrics， Wuxi Children’s Hospital， Wuxi， Jiangsu Province， 214023 China 　　[Abstract] Objective To study the correlation between the MP infection and children with bronchial asthma. Methods 90 cases of children with bronchial asthma treated in our hospital from February 2014 to December 2016 were convenient selected as the asthma group， while 100 cases of respiration tract infection were selected as the control group， and the serum MP antibody， serum EOS， FEV1% pred level and PEF% pred level of various children were tested. Results The MP test positive rate in the asthma group was 46.67%， which was obviously higher than that in the control group（P0.05）， and the serum EOS of MP positive children in the asthma group was（620.02±56.92）×106/L， which was obviously higher than that of MP negative children（P0.05）； the FEV1% pred and PEF% pred levels were respectively （64.81±8.83）% and （63.76±9.86）%， which were obviously lower than those of MP negative children（P0.05）. Conclusion MP infection has a certain correlation with the bronchial asthma in children， which can affect the serum EOS level， and the infection rate of MP in the acute attack stage of asthma is higher. 　　[Key words] Mycoplasma pneumonia； Bronchial asthma； Children 　　支气管哮喘（Bronchial Asthma），简称哮喘，是一种由于机体内免疫系统发生紊乱而导致的变态反应性疾病，主要由肥大细胞、嗜酸性粒细胞和T淋巴细胞等参与，患者多伴有可逆的呼气气流受限，并能够引起各种功能障碍或组织损伤[1-2]。哮喘多