CHF患者血CA125水平与NT―proBNP及LVEF变化关系分析.docVIP

CHF患者血CA125水平与NT―proBNP及LVEF变化关系分析 　　[摘要] 目的 研究慢性心力衰竭（CHF）患者血清CA125、氨基末端?X钠肽前体（NT-proBNP）水平与左室射血分数（LVEF）的关系及临床意义。 方法 选取2015年10月～2017年2月在我院接受治疗的CHF患者120例，按照NYHA分级将患者分为A组（NYHAⅡ级组）、B组（NYHAⅢ级组）和C组（NYHAⅣ级组）。另选取我院体检中心30例健康体检者作为健康对照组，检测每一位研究对象的NT-proBNP、CA125与LVEF，对比分析各组患者NT-proBNP、CA125与LVEF之间的相关性。 结果 （1）CHF患者的CA125和NT-proBNP均显著高于对照组，LVEF显著低于对照组（P0.05），且CA125和NT-proBNP随NYHA分级升高而升高，而LVEF随NYHA分级升高而降低（P0.05）。（2）CHF患者CA125水平与NT-proBNP呈显著正相关，与LVEF呈显著负相关（P0.05）；NT-proBNP与LVEF呈显著负相关（P0.05）。 结论 CHF患者血清CA125与NT-proBNP和LVEF有显著相关性，可联合检测用于判断CHF疾病发生、发展、治疗和预后。 　　[关键词] 慢性心力衰竭；糖类相关抗原125；N末端脑钠肽前体 　　[中图分类号] R541.6 [文献标识码] A [文章编号] 2095-0616（2017）11-187-03 　　Analysis on relationship between serum CA125 level and NT-proBNP and LVEF of CHF patients 　　LIU Qifeng YANG Min LAN Xinping QIU Ruiye CAI Yufu 　　Meizhou Peoples Hospital， Guangdong， Meizhou 514000， China 　　[Abstract] Objective To study the relationship between serum CA125 and N-terminal pro-brain natriuretic peptide （NT-proBNP） level and left ventricular ejection fraction （LVEF） of patients with chronic heart failure （CHF） and its clinical significance. Methods 120 patients with CHF who were treated in our hospital from October 2015 to February 2017 were selected. According to grouping standard of NYHA， patients were divided into group A （NYHAII group）， group B （NYHAIII group） and group C （NYHAIV group）. 30 healthy examined people in physical examination center were selected as the healthy control group. NT-proBNP， CA125 and LVEF of every research object were detected. Correlation of NT-proBNP， CA125 and LVEF of patients in all groups were compared and analyzed. Results （1） CA125 and NT-proBNP of patients with CHF were significantly higher than those of control group while LVEF was significantly lower than that of the control group （P0.05）. CA125 and NT-proBNP increased with increasing NYHA grading while LVEF reduced with increasing NYHA grading （P0.05）. （2） CA125 level of patients with CHF was significantly positively related t