LEEP术后重组人干扰素α―2b阴道泡腾胶囊治疗宫颈高危型HPV感染疗效分析.docVIP

LEEP术后重组人干扰素α―2b阴道泡腾胶囊治疗宫颈高危型HPV感染疗效分析 　　【摘要】 目的 对比分析宫颈环形电切术（LEEP）术后重组人干扰素α-2b阴道泡腾胶囊对宫颈高危型人乳头瘤病毒（HPV）感染患者的临床效果。方法 96例高级别宫颈上皮内瘤变LEEP术后宫颈高危型HPV持续阳性患者， 随机分为对照组和观察组， 各48例。观察组患者实施重组人干扰素α-2b阴道泡腾胶囊治疗， 对照组患者未用药治疗。对比两组患者的临床效果。结果 治疗前， 观察组患者HPV感染率为64.6%， 对照组为62.5%， 比较差异无统计学意义（χ2=0.04， P0.05）。治疗后6个月， 观察组患者HPV感染率为6.3%， 低于?φ兆榈?22.9%， 差异具有统计学意义（χ2=5.35， P0.05）。治疗后12个月， 观察组患者HPV感染率为0， 低于对照组的10.4%， 差异具有统计学意义（χ2=5.27， P0.05）。结论 重组人干扰素α-2b阴道泡腾胶囊用于LEEP术后宫颈高危型HPV感染的治疗， 可以降低多重高危型HPV感染发生率， 具有较高的临床价值， 值得临床推广。 　　【关键词】 重组人干扰素α-2b；高危型人乳头瘤病毒 ；宫颈上皮内瘤变 　　DOI：10.14163/j.cnki.11-5547/r.2017.12.011 　　【Abstract】 Objective To compare and analyze the clinical effect of recombinant human interferon α-2b vaginal effervescent capsule after loop electrical excision procedure （LEEP） in the treatment of cervical high-risk human papilloma virus （HPV） infection. Methods A total of 96 cervical high-risk HPV continuous positive patients of high-level cervical intraepithelial neoplasia after LEEP were randomly divided into control group and observation group， with 48 cases in each group. The observation group received recombinant human interferon α-2b vaginal effervescent capsule for treatment， and the control group received no drug therapy. Clinical effect was compared in two groups. Results Before treatment， the observation group had HPV infection rate as 64.6%， which was 62.5% in the control group， and the difference had no statistical significance （χ2=0.04， P0.05）. After 6 months of treatment， the observation group had lower HPV infection rate as 6.3% than 22.9% in the control group， and the difference had statistical significance （χ2=5.35， P0.05）. After 12 months of treatment， the observation group had lower HPV infection rate as 0 than 10.4% in the control group， and the difference had statistical significance （χ2=5.27， P0.05）. Conclusion Recombinant human interferon α-2b vaginal effervescent capsule has high clinical value in the treatment of cervical high-risk HPV infection after LEEP， and it can re