NAPPCT联合检测在肺炎支原体肺炎诊断中价值.docVIP

NAPPCT联合检测在肺炎支原体肺炎诊断中价值 　　[摘要] 目的 探讨外周血中性粒细胞碱性磷酸酶（NAP）、血清降钙素原（PCT）联合检测在肺炎支原体肺炎（MPP）诊断中的价值。 方法 方便选取2011年6月―2016年6月确诊的肺炎支原体肺炎患者共450例。采用电化学发光法对诊断为肺炎支原体肺炎患者血清降钙素原（PCT）水平进行检测，同时采用化学染色法检测其外周血中性粒细胞碱性磷酸酶（NAP）活性，并与60名健康对照组比较。结果 肺炎支原体肺炎组NAP阳性率72.22%，积分（88.7±13.4）分；PCT阳性率82.44%，水平值（0.301±0.123）μg/mL，两者同时表达阳性率64.44%，特异性99.5%。与健康对照组（NAP阳性率30.00%，积分（61.2±11.3）分；PCT阳性率1.67%，水平值（0.034±0.013）μg/mL比较差异有统计学意义（P0.01）。结论 由于PCT受不同病原体影响较大，NAP则相对稳定，两者联合检测在肺炎支原体肺炎的早期诊断和合理用药方面有较高价值。 　　[关键词] 肺炎支原体肺炎；外周血中性粒细胞碱性磷酸酶；降钙素原 　　[中图分类号] R5 [文献标识码] A [文章编号] 1674-0742（2017）11（a）-0029-03 　　[Abstract] Objective To study the value of combined test of NAP and PCT in diagnosis of mycoplasmal pneumonia. Methods 450 cases of patients with mycoplasmal pneumonia diagnosed in our hospital from June 2011 to June 2016 convenient were selected and the PCT level of patients with mycoplasmal pneumonia was tested by the electrochemiluminescence， the NAP activity was tested by the immunohistochemistry， and the results were compared with those of 60 cases of healthy people in the control group. Results The positive rate of NAP in the mycoplasmal pneumonia group， integral， positive rate of PCT and level value were respectively 72.22%，（88.7±13.4）points， 82.44%，（0.301±0.123）μg/mL， and the expression positive rate and specificity were respectively 64.44% and 99.5%， and the differences between the two groups were obvious， （in the control group： NAP positive rate 30.00%， integral（61.2±11.3）points， PCT positive rate 1.67%， level value（0.034±0.013）μg/mL（P0.01）. Conclusion The value of combined test of NAP and PCT in the early diagnosis and rational medication of mycoplasmal pneumonia is high due to the big effect of different pathogens on PCT and relatively steady NAP. 　　[Key words] Mycoplasmal pneumonia； NAP； PCT 　　肺炎支原?w肺炎（MPP）是一种由肺炎支原体引起的间质性肺炎，占非细菌性肺炎的1/3以上，广泛存在于全球范围内[1-2]。我国肺炎支原体肺炎的发病率相对更高，且无性别、年龄差别。近年来呈明显上升趋势，并可引发肺外多系统的并发症[3-4]。因此早期诊断和治疗尤其重要。该研究通过对450例肺炎支原体肺炎患者（患者均来自该院，为2011年6月―2016年6月期间门诊以及住院确诊患者）NAP、PCT进行联合检测，旨在探讨对