P16ERCEA在宫颈腺癌和子宫内膜癌鉴别诊断中临床意义.docVIP

P16ERCEA在宫颈腺癌和子宫内膜癌鉴别诊断中临床意义 　　【摘要】 目的：观察和分析P16、ER、CEA蛋白在子宫颈腺癌和子宫内膜腺癌中的表达及其临床意义。方法：采用SP免疫组化法检测32例子宫颈腺癌和32例子宫内膜腺癌中P16、ER、CEA蛋白的表达情况，并进行回顾性分析。结果：P16、ER、CEA在子宫颈腺癌中阳性表达率分别为65.63%（21/32）、28.13%（9/32）、81.25%（26/32），而在子宫内膜腺癌中分别为9.36%（3/32）、75.00%（24/32）、43.75%（14/32）。子宫颈腺癌P16、CEA阳性表达率高于子宫内膜腺癌（P0.05）。子宫内膜腺癌ER的阳性率明显高于子宫颈腺癌（P0.05）。结论：ER、P16和CEA蛋白联合检测表达可作为鉴别宫颈腺癌和子宫内膜腺癌的辅助诊断方法，有较好的临床应用价值。 　　【关键词】 P16； ER； CEA； 子宫颈腺癌； 子宫内膜腺癌 　　Analysis on Clinical Significance of P16，ER and CEA Joint Detection of the Cervical Adenocarcinoma and the Endometrial Carcinoma/YANG Wei-hong，ZHONG Shou-jun，DUAN Li-feng，et al.//Medical Innovation of China，2015，12（18）：036-038 　　【Abstract】 Objective：To observe and analysis the P16，ER and CEA protein expression in the cervical adenocarcinoma and endometrial adenocarcinoma and their clinical significance.Method：Immunohistoehemical method was used to detect P16，ER and CEA in paraffin-embedded tissues from 32 cases of endocervicaI adenocarcinomas and 32 cases of endometrial adenocarcinomas.The expression of P16，ER and CEA were retrospectively analyzed.Result：The positive rates of P16，ER，CEA in the cervical adenocarcinoma were 65.63%（21/32），28.13%（9/32），81.25%（26/32），respectively；those in endocervicaI adenocarcinoma were various 9.36%（3/32），75.00%（24/32），43.75%（14/32）.P16 and CEA in the cervical adenocarcinoma positive expression rate were higher than those of endometrial adenocarcinoma（P0.05）.Endometrial adenocarcinoma in the positive rate of ER was obviously higher than that of the cervical adenocarcinoma（P0.05）.Conclusion：Joint detection expression of P16，ER and CEA protein has great clinical application value in the differential diagnosis of endocervical and endometrial adenocarcinomas. 　　【Key words】 P16； ER； CEA； Cervical adenocarcinoma； Endometrial adenocarcinoma 　　First-author’s address：The Boai Hospital of Zhongshan，Zhongshan 528403，China 　　doi：10.3969/j.issn.1674-4985.2015.18.013 　　宫颈腺癌（cervical adenocarcinoma）较鳞癌少见，而近年来有研究显示，与宫颈鳞癌相比，宫颈原发腺癌发病率