P16和Ki―67在宫颈鳞癌癌前病变中表达及其诊断价值分析构架.docVIP

P16和Ki―67在宫颈鳞癌癌前病变中表达及其诊断价值分析构架 　　[摘要] 目的 探讨Ki-67与P16这两项免疫组化细胞增殖标志指数在宫颈鳞癌癌前病变中的具体表达，分析其架构，并验证其所具有的诊断价值。 方法 择取2011年11月～2016年11月期间于笔者所在医院行宫颈癌筛查的90例受检对象，其中包括30例健康受检者，30例宫颈鳞状上皮内瘤变患者以及30例宫颈鳞癌患者，分别命名为A组、B组与C组。为三组受检者给予免疫组化检测，分析各组的Ki-67与P16表达。 结果 就Ki-67与P16的阳性表达率而言，C组B组A组，CIN（Cervical Intraepithelial Neoplasia，宫颈上皮内瘤变）ⅢCIN Ⅱ CIN Ⅰ，病变越严重，阳性表达率越高，且C组、B组分别与A组比较，差异有统计学意义（P0.05）。 结论 Ki-67与P16阳性表达率与患者宫颈组织病变程度轻重有较为密切的联系，临床可以根据Ki-67与P16的表达结果来鉴别患者宫颈组织的病变程度，给予患者准确的诊断。 　　[关键词] P16；Ki-67；宫颈鳞癌癌前病变；表达；诊断价值 　　[中图分类号] R737.33 [文献标识码] A [文章编号] 2095-0616（2017）14-203-03 　　Expression of P16 And Ki-67 in precancerous lesions and its diagnostic value in cervical squamous cell carcinoma 　　WANG Xiaoping 　　Department of Gynaecology，Dongguan Huangjiang Hospital，Dongguan 523400，China 　　[Abstract] Objective To investigate the expression of Ki-67 and P16 immunohistochemical markers in precancerous lesions of cervical squamous cell carcinoma，and to analyze their structure and verify their diagnostic value. Methods 90 patients with cervical cancer screening in the hospital from November 2011 to November 2016 were enrolled，including 30 healthy subjects 30 patients with cervical squamous intraepithelial neoplasia，and 30 patients with cervical squamous cell carcinoma，they were named group A，group B and group C，respectively.The expression of Ki-67 and P16 in each group was analyzed by immunohistochemistry. Results The order of positive rate of Ki-67 and P16 was group CBA group，CIN ⅢCIN ⅡCIN Ⅰ，and the more serious the lesion，the higher the positive expression rate.Compared group B and group C with group A，the differences were statistically significant （P0.05）. Conclusion Ki-67 and P16 positive expression rate has a more closely link with the severity of cervical lesions in patients.The expression of Ki-67 and P16 can be used to identify the degree of cervical tissue and provide accurate diagnosis. 　　[Key words] P16；Ki-67；Precancerous lesions of cervical squamous cell carcinoma；Expression；Diagnostic v