EV71检测血糖外周血白细胞在小儿重症手足口病早期识别中应用.docVIP

EV71检测血糖外周血白细胞在小儿重症手足口病早期识别中应用 　　【摘要】 目的：探?小儿手足口病（hand-foot-mouth disease，HFMD）患儿肠道病毒71型（Enterovirus 71，EV71）检测、血糖、外周血白细胞水平对病情发展的临床诊断意义。方法：回顾性分析2014年 　　1月-2016年12月本院180例小儿手足口病（HFMD）患儿EV71检测阳性率及治疗前后不同病程分期（Ⅰ、Ⅱ、Ⅲ期）血糖、外周血白细胞计数变化情况。结果：Ⅰ、Ⅱ、Ⅲ期患儿阳性率分别为75.00%、81.42%和96.67%，Ⅲ期患儿EV71阳性率明显高于Ⅰ、Ⅱ期（P0.05），Ⅱ期患儿EV71阳性率又高于Ⅰ期患儿（P0.05）。治疗时：Ⅲ期患儿血糖、外周白细胞计数明显高于Ⅰ、Ⅱ期患儿（P0.05），而Ⅱ期患儿血糖、外周白细胞计数又高于Ⅰ期患儿（P0.05）。治疗后：Ⅰ、Ⅱ、Ⅲ期患儿空腹血糖及外周血白细胞计数均有所下降，且Ⅲ期较Ⅰ、Ⅱ期下降更明显（P0.05）。结论：EV71阳性、血糖升高、外周血白细胞计数升高可作为小儿重症手足口病早期识别的重要指标，及早防治干预可以缩短手足口病患儿病程，并改善预后，为临床早期识别手足口病病情发展提供有效依据。 　　【关键词】 手足口病； 肠道病毒71型； 血糖； 外周血白细胞； 早期识别 　　Application of EV71 Detection，Blood Glucose and Peripheral Blood Leukocyte in Early Identification of Severe Hand，Foot and Mouth Disease in Children/XIONG Zhi-yong，LIU Jing.//Medical Innovation of China，2017，14（10）：020-023 　　【Abstract】 Objective：To investigate the clinical diagnostic value of enterovirus 71（Enterovirus，EV71），blood glucose and peripheral blood leukocyte levels in children with hand，foot and mouth disease（hand-foot-mouth disease，HFMD）.Method：From January 2014 to December 2016 in our hospital，EV71 positive rate and changes of blood glucose and peripheral blood leukocyte count in different stages（stage Ⅰ，Ⅱ，Ⅲ） before and after treatment in 180 cases of children with hand，foot and mouth disease（HFMD） were retrospective analysed.Result：EV71 positive rate of children with stage Ⅰ，Ⅱ and Ⅲ respectively were 75.00%，81.42% and 96.67%，positive rate of children with stage Ⅲ was significantly higher than that of children with stage Ⅰ and Ⅱ（P0.05），positive rate of children with stage Ⅱ was higher than that of children with stage I（P0.05）.During treatment，blood glucose and peripheral white blood cell count of stage Ⅲ patients were significantly higher than those of stage Ⅰ and Ⅱ patients（P0.05），stage Ⅱ patients blood glucose，peripheral white blood cell count was higher than stage Ⅰ patients（P0.05）.After treatment，fasting blood glucose and white blood cells the count of phase Ⅰ，Ⅱ，Ⅲ patients were all