七氟醚与异氟醚吸入麻醉对腹腔镜胆囊切除术患者麻醉后苏醒及认知功能影响.docVIP

七氟醚与异氟醚吸入麻醉对腹腔镜胆囊切除术患者麻醉后苏醒及认知功能的影响 　　[摘要] 目的 探讨七氟醚与异氟醚吸入麻醉对腹腔镜胆囊切除术患者麻醉后苏醒及认知功能的影响。 方法 100例腹腔镜胆囊切除术患者随机分为观察组与对照组，分别采用七氟醚和异氟醚吸入麻醉。 结果 观察组自主呼吸恢复时间、睁眼时间、拔管时间和定向力恢复时间均短于对照组（P0.05）。两组治疗期间无明显药物不良反应。 结论 腹腔镜胆囊切除术患者采用七氟醚吸入麻醉具有苏醒更快，睁眼、拔管时间更短，苏醒期躁动发生率低，安全性较好等优点。 　　[关键词] 七氟醚；异氟醚；腹腔镜胆囊切除术；麻醉后苏醒；认知功能 　　[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701（2014）36-0134-03 　　Influence of sevoflurane and isoflurane inhalation anesthesia on postanesthetic analepsia and cognitive function of patients with laparoscopic cholecystectomy 　　YU Zhenwei 　　Department of Anesthesiology， Yinzhou People’s Hospital of Ningbo City in Zhejiang Province， Ningbo 315000， China 　　[Abstract] Objective To discuss influence of sevoflurane and isoflurane inhalation anesthesia on postanesthetic analepsia and cognitive function of patients with laparoscopic cholecystectomy （LC）. Methods 100 cases of patients planned to be treated by LC operation were selected and divided into observation group and control group randomly. The patients in observation group were given sevoflurane inhalation anesthesia， while the patients in control group were given isoflurane inhalation anesthesia. Results The spontaneous breathing recovery time， EO time， extubation time， and orientation recovery time of patients in observation group were all much shorter than those in control group （P0.05）. There were no obvious adverse drug reaction（ADR） during treatment in two groups. Conclusion The application of sevoflurane inhalation anesthesia on patients with LC has the virtue of shorter analepsia time， EO time， extubation time， low incidence rate of agitation in up period， weaker influence on cognitive function and best safety. 　　[Key words] Sevoflurane； Isoflurane； Laparoscopic cholecystectomy（LC）； Postanaesthetic recovery； Cognitive function 　　认知功能障碍是麻醉术后常见的中枢系统并发症，好发于老年患者，表现为精神错乱、焦虑、人格改变以及记忆受损，严重影响患者术后恢复，甚至可能导致患者死亡[1，2]。术后认知功能障碍发生机制较复杂，与年龄、手术方式及麻醉药物等因素相关[3，4]。本研究观察七氟醚吸入麻醉对腹腔镜胆囊切除术患者麻醉后苏醒及认知功能的影响，现报道如下。 　　1 资料与方法 　　1.1一般资料 　　选择2012年