三氧治疗联合调强适形放疗治疗鼻咽癌及对患者血清乏氧诱导因子1α及血管内皮生长因子影响.docVIP

三氧治疗联合调强适形放疗治疗鼻咽癌及对患者血清乏氧诱导因子-1α及血管内皮生长因子的影响 　　[摘要]目的 研究分析三氧治疗联合调强适形放疗治疗鼻咽癌的疗效及对患者血清乏氧诱导因子-1α（HIF-1α）及血管内皮生长因子（VEGF）的影响。方法 选取我院2010年1月～2013年12月收治的鼻咽癌放疗患者50例进行治疗观察，随机分为两组，每组各25例。对照组行调强放疗，观察组在对照组治疗基础上行三氧联合治疗。结果 治疗后，观察组鼻咽癌患者血清HIF-1α水平显著下降，对照组则显著升高，差异均有统计学意义（P＜0.01～0.05）。治疗后，观察组鼻咽癌患者血清HIF-1α水平显著低于对照组，差异有统计学意义（P＜0.01）。治疗后，观察组鼻咽癌患者血清VEGF水平显著下降，对照组则显著升高，差异均有统计学意义（P＜0.01）。治疗后，观察组鼻咽癌患者血清VEGF水平显著低于对照组，差异有统计学意义（P＜0.01）。结论 三氧治疗联合调强适形放疗治疗鼻咽癌的疗效显著，能改善患者的血清乏氧诱导因子-1α及血管内皮生长因子水平。 　　[关键词] 鼻咽癌；放疗；三氧治疗；乏氧诱导因子-1α；血管内皮生长因子 　　[中图分类号] R739.6#8195;#8195;#8195;[文献标识码] A#8195;#8195;#8195;[文章编号] 2095-0616（2014）08-36-03 　　 　　Three-oxygen therapy combined with intensity modulated radiation therapy used for treatment of nasopharyngeal cancer and its influence on patients serum hypoxia inducible factor-1α and vascular endothelial growth factors 　　WANG#8195;Xiuwen#8195;#8195;YI#8195;Jiqun#8195;#8195;PAN#8195;Zhaojun#8195;#8195;LIANG#8195;Jizhen 　　Department of Tumors,Guangzhou Red Cross Hospital,Guangzhou 510220,China 　　[Abstract] Objective To study and analyze the efficacy of three-oxygen therapy combined with intensity modulated radiation therapy in the treatment of nasopharyngeal cancer and its influence on the patients serum hypoxia inducible factor-1(HIF-1α) and vascular endothelial growth factors(VEGF). Methods Fifty patients with nasopharyngeal cancer treated in our hospital from January 2010 to December 2013 were selected to receive treatment and randomly divided into two groups.The control group received intensity modulated radiation therapy and the observation group received three-oxygen therapy on the basis of the control group. Results After treatment, the serum HIF-1α level of the observation group reduced significantly and that of the control group elevated significantly,with statistically significant differences for both(P＜0.01-0.05).After treatment, the serum HIF-1α level of the observation group was significantly lower than that of the control group, with statistically sig