不同剂量美托洛尔治疗不稳定型心绞痛疗效及对血糖影响临床研究.docVIP

不同剂量美托洛尔治疗不稳定型心绞痛的疗效及对血糖影响的临床研究 　　【摘要】 目的：探讨不同剂量的美托洛尔治疗不稳定型心绞痛的疗效，及对血糖水平的影响。方法：选择2014年12月-2015年12月年来本院进行治疗的120例不稳定型心绞痛合并2型糖尿病患者进行调查分析，分为低剂量组、常规剂量组和高剂量组，每组各40例。低剂量组采用美托洛尔缓释片23.75 mg口服，1次/d；常规剂量组予美托洛尔缓释片47.5 mg口服，1次/d；而高剂量组予美托洛尔缓释片95 mg口服，1次/d。结果：治疗3个月后，高剂量组和常规剂量组空腹血糖水平明显低于治疗前，差异均有统计学意义（P0.05）；与低剂量组相比，高剂量组、常规剂量组治疗后的空腹血糖均明显降低，差异均有统计学意义（P0.05）。结论：美托洛尔治疗不稳定型心绞痛有效，安全的剂量范围易于在临床应用，具有广泛的实用价值，值得在临床推广研究。 　　【关键词】 美托洛尔； 不稳定型心绞痛； 血糖水平； 疗效 　　【Abstract】 Objective：To investigate the efficacy of different doses of Metoprolol in the treatment of unstable angina pectoris， and their effects on blood glucose levels.Method：120 patients of unstable angina pectoris with type 2 diabetes were selected from December 2014 to December 2015 in our hospital for treatment， they were investigated and divided into low dose group，conventional dose group and high dose group，40 cases in each group.Low dose group received Metoprolol sustained-release tablets was 23.75 mg oral，conventional dose group received Metoprolol sustained-release tablets was 47.5 mg oral， and high dose group was given Metoprolol sustained-release tablets of 95 mg oral，which all oral once a day.Result：After treatment of 3 months， the fasting blood glucose levels of high dose group and conventional dose group were significantly lower than that before treatment，the differences were statistically significant（P0.05）.After treatment，compared with the low dose group，the fasting blood glucose of high dose group and conventional dose group significantly decreased，the differences were statistically significant（P0.05）.Conclusion：Metoprolol in the treatment of unstable angina pectoris is effectively，the safe dose range easily in clinical application，with extensive practical value and it is worth to be popularized in clinical research. 　　【Key words】 Metoprolol； Unstable angina pectoris； Blood glucose level； Therapeutic effect 　　First-author’s address：Gaoyao People’s Hospital，Gaoyao 526040，China 　　doi：10.3969/j.issn.1674-4985.2016.19.01