不同时间应用丙种球蛋白治疗川崎病疗效分析.docVIP

不同时间应用丙种球蛋白治疗川崎病的疗效分析 　　[摘要] 目的 探讨不同时间应用静脉注射丙种球蛋白（IVIG）治疗川崎病的临床疗效。 方法 整群选择2004年1月―2015年6月间该院收治的99例川崎病患儿根据IVIG的时间分为A组（1～5 d，n=22）、B组（5～10 d，n=48）、C组（10 d，n=29），比较各组治疗后实验室指标及丙种球蛋白无反应发生率及冠脉病变发生率。 结果 三组患儿治疗后血CRP、血沉及血小板比较，差异均无统计学意义（P0.05）；A组患儿丙种球蛋白无反应发生率明显高于B组、C组，差异有统计学意义（P0.05）；C组患儿冠脉病变发生率明显高于A组、B组，差异有统计学意义（P0.05）。 结论 川崎病发病5-10 d静脉应用丙种球蛋白治疗时患儿的丙种球蛋白无反应发生率及冠脉病变发生率均相对较低。 　　[关键词] 川崎病；丙种球蛋白；冠状动脉瘤 　　[中图分类号] R725.4 [文献标识码] A [文章编号] 1674-0742（2016）02（a）-0120-03 　　Analysis of Curative Effect of the Application of Gamma Globulin at Different Times in Treatment of Kawasaki Disease 　　WU Zhan-fan， HU Xiang 　　Pediatrics， The Second Affiliated Hospital of Guangzhou Medical University， Guangzhou， Guangdong province， 510000 China 　　[Abstract] Objective To discuss the clinical curative effect of the application of intravenous immunoglobulin （IVIG）in treatment of Kawasaki disease. Methods 99 cases of children with Kawasaki disease treated in our hospital from January 2004 to June 2015 were selected and divided into group A（1～5 d，n=22）， group B （5～10 d，n=48）、and group C （10 d，n=29） according to the IVIG times， after treatment ， the laboratory index ， the incidence of gamma globulin non-response and the incidence of coronary artery lesions of the three groups were compared. Results After treatment， the differences in the blood CRP， erythrocyte sedimentation rate and platelet between the three groups were not statistically significant （P0.05）； the incidence of gamma globulin non-response in group A was obviously higher than that in group B and group C， and the difference was statistically significant （P0.05）； the incidence of coronary artery lesions in group C was obviously higher than that in the group A and group B， and the difference was statistically significant （P0.05）. Conclusion The incidences of gamma globulin non-response and coronary artery lesions are relatively low by the application of IVIG on the 5-10d after onset of Kawasaki disease. 　　[Key words] Kawasaki disease； G