中医痰热清注射液辅助治疗脓毒症对病情进展和死亡率干预作用.docVIP

中医痰热清注射液辅助治疗脓毒症对病情进展和死亡率的干预作用 　　[摘要]目的 观察痰热清注射液辅助治疗对脓毒症患者病情的改善情况和死亡率的干预作用。方法 选取2013年5月～2016年5月来我院进行治疗的脓毒症患者90例，按照随机数字表法将90例患者分为观察组和对照组，每组各45例。对照组采用西医常规治疗，观察组则在西医常规治疗的基础上辅以痰热清注射液，治疗7 d后，观察炎症相关指标的变化，包括C反应蛋白（CRP）、血液降钙素原（PCT）、白细胞介素-6（IL-6）、白细胞介素-8（IL-8）、肿瘤坏死因子-α（TNF-α）；记录治疗前后急性生理学及慢性健康状况Ⅱ（APACHE Ⅱ）评分；治疗21 d后，统计疗效和死亡率；统计治疗过程中出现的不良反应并发率。结果 治疗7 d后观察组的CRP、PCT、IL-6、IL-8、TNF-a改善效果优于对照组，且差异有统计学意义（P0.05）。观察组休克、深静脉血栓的发生率均低于对照组，差异有统计学意义（P0.05）。结论 痰热清注射液在降低脓毒症患者炎症反应、改善临床症状、降低死亡率方面具有一定的疗效。 　　[关键词]痰热清注射液；脓毒症；炎症反应；病情改善；疗效 　　[中图分类号] R631 [文献标识码] A [文章编号] 1674-4721（2017）05（c）-0025-03 　　[Abstract]Objective To observe the mend matters of sepsis and intervention effects of death rate with Tanreqing Injection.Methods 90 sepsis patients in our hospital from May 2013 to May 2016 were selected and divided into observation group and control group by the method of random number table，45 cases in each group.The control group was treated with normal western medicine，while the observation group was treated with Tanreqing Injection additional on the basis of normal western medicine.After 7 days of treatment，the changes of inflammatory marks including CRP，PCT，IL-6，IL-8，TNF-α were observed.APACHE Ⅱ was recorded before and after treatment.After 21 days of treatment，the curative effect and death rate were counted.Results After 7 days of treatment，the observation group had better improvement effects on CRP，PCT，IL-6，IL-8，TNF-a than the control group，with statistically significant differences （P0.05）.The observation group had lower incidence rates of shock and deep venous thrombosis than the control group with statistically significant differences （P0.05）.Conclusion Tanreqing Injection can reduce sepsis patients′ inflammation，improve clinical symptoms and cut the death rate. 　　[Key words]Tanreqing Injection；Sepsis；Inflammatory reaction；Condition improvement；Curative effect 　　?毒症是重症医学的常见、多发病，也是急救医学方面处理起来比较困难的疾病，可以引起危重病患者的死亡[1]。其主要病理特征是大量的炎症因子被激活并释放到全身各处，呈“瀑布效应”，对器官组织造成伤害，因此抑制或降低炎症因子的数量已然成为急救的关键[2]。目