中波高能紫外线联合0.03%他克莫司软膏治疗儿童白癜风效果及安全性分析.docVIP

中波高能紫外线联合0.03%他克莫司软膏治疗儿童白癜风的效果及安全性分析 　　[摘要]目的 ?^察对儿童白癜风采用中波高能紫外线联合0.03%他克莫司软膏治疗的安全性及对治疗影响因素的分析。方法 将2014年3月～2017年3月在我院就诊的120例儿童白癜风患者作为研究对象，收集其临床资料进行回顾性分析；按照治疗方案不同，将患儿分成观察组和对照1组、对照2组，每组各40例。观察组患儿采用中波高能紫外线联合0.03%他克莫司软膏治疗，1～2次/周，12周为1疗程；对照1组患儿采用单纯紫外线治疗，对照2组仅给予他克莫司软膏外涂，分析三组患儿治疗效果、影响因素及安全性。结果 观察组患儿治疗总有效率为67.50%（27/40），显著高于对照1组的50.00%（20/40）和对照2组的42.5%（17/40），差异有统计学意义（P0.05）；观察组患儿皮损复色起始时间（1.52±0.66）个月，显著低于对照1组的（1.90±0.95）个月和对照2组的（1.95±0.90）个月，差异有统计学意义（P0.05）；观察组患儿头面部、躯干部、四肢及肢端有效率均高于对照1组、对照2组，差异有统计学意义（P0.05）；观察组患儿初次治疗不良反应发生率为45.00%，与对照1组的45.00%一致，但高于对照2组的40.00%，对照1组、对照2组差异无统计学意义（P0.05）。结论 对儿童白癜风采用中波高能紫外线联合0.03%他克莫司软膏治疗，其治疗效果主要受部位、病程、治疗频率影响，副作用较小，安全性较高，效果理想，值得临床推广。 　　[关键词]中波高能紫外线；他克莫司软膏；儿童白癜风；治疗效果；安全性；影响因素分析 　　[中图分类号] R758.41 [文献标识码] A [文章编号] 1674-4721（2018）1（c）-0036-03 　　Efficacy and safety analysis of medium-wave high-energy ultraviolet irradiation combined with 0.03% Tacrolimus Ointment in the treatment of children with vitiligo 　　LIANG Xing-long YAN Jun FENG Fan 　　Department of Dermatology，Maoming People′s Hospital，Guangdong Province，Maoming 525000，China 　　[Abstract]Objective To observe the safety of medium-wave high-energy ultraviolet irradiation combined with 0.03% Tacrolimus Ointment in the treatment of vitiligo in children and the analysis of its influencing factors.Methods A total of 120 patients diagnosed as pediatric vitiligo treated in our hospital from March 2014 to March 2017 were selected as research objects.Their clinical data were collected and analyzed retrospectively.According to the different therapeutic regimen，they were divided into the observation group，control group 1，and control group 2 evenly.In the observation group，40 cases were treated with medium-wave high-energy ultraviolet irradiation combined with 0.03% Tacrolimus Ointment，1 to 2 times per week，12 weeks for one course of treatment.In the control group 1，only ultraviolet radiation was used，and in the control group 2，only external application of Tacrolimus Ointment was adopted.The thera