乳腺癌患者CEACA125CA153检测及其与生活质量相关性分析.docVIP

乳腺癌患者CEA、CA125、CA153检测及其与生活质量的相关性分析 　　[摘要] 目的 研究乳腺癌患者血清中CEA、CA125、CA153的水平及其与生活质量的相关性。方法 选择乳腺癌患者作为观察组、乳腺良性疾病患者作为良性对照组、健康体检者作为健康对照组，检测外周血中CEA、CA125、CA153的含量并观察生活质量相关指标。 结果 观察组患者CEA、CA125、CA153水平以及躯体功能、心理功能、社会功能、认知功能、总体生活质量评分明显高于良性对照组和健康对照组；躯体功能、心理功能、社会功能、认知功能、总体生活质量评分与CEA、CA125、CA153水平呈负相关。 结论 CEA、CA125、CA153检查对乳腺癌的诊断具有积极的临床价值，且与生活质量密切相关。 　　[关键词]乳腺癌；癌胚抗原；肿瘤标志物；生活质量 　　[中图分类号] R739.9 [文献标识码] B [文章编号] 2095-0616（2013）13-123-03 　　Detection CEA，CA125，CA153 in breast cancer patients and its correlation with quality of life 　　PAN Zhonghua 　　Department of Clinical laboratory，Daye Iron Mine Hospital，Wuhan Iron and Steel，Huangshi 435006，China 　　[Abstract] Objective To study the level of CEA，CA125，CA153 in breast cancer patients and its correlation with quality of life. Methods the breast cancer patients were selected as observation group，benign breast disease patients as benign control group， and healthy people as healthy control group，the peripheral blood levels of CEA，CA125， CA153 were detected and quality of life were observed. Results The CEA，CA125，CA153 levels and physical function，psychological function，social function，cognitive function，overall quality of life scores of observation group were significantly higher than benign control group and healthy control group； physical function，psychological function，social function，cognitive function，overall quality of life score were negatively correlated with CEA，CA125，CA153 levels. Conclusion The clinical value of positive CEA，CA125，CA153 examination in the diagnosis of breast cancer，which is closely related with the quality of life. 　　[Key words] Breast cancer；Tumor markers；Carcinoembryonic antigen；Quality of life 　　乳腺癌是女性最常见的恶性肿瘤，给女性健康带来了灾难性的恐慌，严重影响其生活质量。但是目前对于乳腺癌仍缺乏有效的早期诊断指标。因此，寻找乳腺癌的早期诊断指标成为了近年来临床和基础研究的热点。在下列研究中我们分析了乳腺癌患者CEA、CA125、CA153检测及其与生活质量的相关性，旨在为临床中寻找乳腺癌的早期诊断方式及患者生活质量状况提供更多的理论依据。 　　1 资料与方法 　　1.1 一般资料 　　选择2007年5月～2012年3月期间在我院就诊的150名乳腺癌患者的作为本次前瞻性研究的观察组，100名同期在我院就诊的乳腺良性疾病患者作为良性对照组，100名同期在我院体检的健康女性作为健康对照组。3组入