亚低温联合颅内血肿微创清除术治疗重症高血压脑出血临床随机对照研究.docVIP

亚低温联合颅内血肿微创清除术治疗重症高血压脑出血的临床随机对照研究 　　【摘要】 目的：探讨亚低温联合颅内血肿微创清除术治疗重症高血压脑出血的临床效果。方法：选取2013年8月-2016年5月本院神经外科收治的重症高血压脑出血患者100例作为本次研究对象，将其按照随机数字表法分为对照组和观察组，每组50例。对照组在常规对症治疗基础上给予颅内血肿微创清除?g治疗，观察组在常规对症治疗基础上给予亚低温联合颅内血肿微创清除术治疗，治疗后对两组患者进行为期8周的随访观察。采用美国国立卫生研究院卒中量表（National Institute of Health stroke scale，NIHSS）对两组患者治疗前、治疗后3 d的神经功能情况进行评价，并分别于治疗后2、8周采用Fugl-Meyer运动功能评定（Fugl-Meyer Motor Function Assessment，FMA）量表对患者运动功能进行评分，观察比较两组临床总有效率、残留血肿量、再出血率、治疗前后NIHSS评分、FMA评分和不良反应发生率。结果：（1）观察组临床总有效率为90.0%，明显高于对照组的68.0%，差异有统计学意义（P0.05）；治疗后，两组NIHSS评分、FMA评分均明显优于治疗前，且观察组明显优于对照组，差异均有统计学意义（P0.05）。（4）观察组不良反应（感染、静脉血栓、肩手综合征、足内翻、足下垂）发生率为10.0%，明显低于对照组的36.0%，差异有统计学意义（P0.05）。结论：临床上采用亚低温联合颅内血肿微创清除术治疗重症高血压脑出血，疗效显著，可显著改善神经功能及运动功能，提高患者治疗后的生活质量，且治疗过程中不良反应少，安全性高，具有较高的临床应用价值。 　　【关键词】 亚低温； 颅内血肿微创清除术； 重症高血压脑出血； 临床效果 　　Clinical Randomized Controlled Study on Mild Hypothermia Combined with Minimally Invasive Removal of Intracranial Hematoma in the Treatment of Severe Hypertensive Cerebral Hemorrhage/XIAO Wang.//Medical Innovation of China，2017，14（05）：031-035 　　【Abstract】 Objective：To explore the clinical effect of mild hypothermia combined with minimally invasive removal of intracranial hematoma in the treatment of severe hypertensive cerebral hemorrhage.Method：In the Department of Neurosurgery of our hospital from August 2013 to May 2016 100 cases of severe hypertensive intracerebral hemorrhage were selected as the research objects，and randomly divided into the control group and the treatment group，50 cases in each group.The control group on the basis of conventional symptomatic treatment was given intracranial hematoma removal treatment，the observation group on the basis of the conventional symptomatic treatment was given mild hypothermia combined with minimally invasive intracranial hematoma treatment，after treatment patients of two groups were observed for a period of 8 weeks of follow-up.The National Institutes of Health Stroke Scale（National Institute of Health stroke scale，NIHSS） were used to evaluate the