介孔二氧化硅纳米粒在抗肿瘤药物靶向给药系统中应用.docVIP

介孔二氧化硅纳米粒在抗肿瘤药物靶向给药系统中的应用 　　[摘要]化学疗法是治疗癌症的主要疗法之一，但传统抗肿瘤药在体内呈全身性分布，肿瘤组织内很难达到有效药物浓度，且自身又不具备辨别正常细胞与肿瘤细胞的能力，易造成全身毒性反应，已远远不能满足临床需要。近几年，随着纳米技术的发展及普遍应用，纳米靶向抗肿瘤药物的研究取得了突破性的进展，其中介孔二氧化硅纳米粒（MSNs）在抗肿瘤药物靶向给药系统中的研究日益增多，因其特有的结构及理化特征，具有作用于特定靶点，直接抑制肿瘤细胞的生长，减少对正常细胞和组织器官的毒副作用，可以长期用药等优点，有望成为抗癌药物的优良载体，对MSNs在癌症治疗领域的应用也已成为现在医药领域的研究热点。该文对2008―2015年MSNs在抗肿瘤药物靶向给药系统的最新研究作一综述，分别介绍了MSNs在抗肿瘤药物被动靶向、主动靶向、物理或化学条件响应型靶向及其他复合靶向给药系统中的应用，以期对目前具有良好抗肿瘤作用的化药、天然药物及中药单体化合物的减毒增效及进一步开发提供参考。 　　[关键词]介孔二氧化硅;抗肿瘤药物;靶向给药系统 　　Progress of mesoporous silica nanoparticles in targeting drug 　　delivery system of antitumor drug 　　ZHANG Hong-min1，2 ， MO Shu1，2， LIU Xiao-qian2， HAN Fu-man2， WANG Jin-yu2*， WANG Zhi-min2* 　　（1.Tianjin University of Traditional Chinese Medicine， Tianjin 300193， China; 　　2.Institute of Chinese Materia Madica， China Academy of Chinese Medical Sciences， Beijing 100700， China） 　　[Abstract]Currently， chemotherapy is one of the main therapy for cancer. But the traditional antitumor drugs are systemic distribution in vivo， they are difficult to achieve an effective drug concentration in the tumor tissue and don′t have the ability to distinguish normal cells and tumor cells by themselves， that cause systemic toxicity easily and can not meet the clinical needs. With the research on mesoporous silica nanoparticles （MSNs） deepening， more and more attention in the drug delivery system have been payed to in recent years， because of its unique physicochemical structure characteristics， it has the effect on specific targets， directly inhibits the tumor cell growth， reduces the side effects to normal cells ， tissues and organs and can be long-term medication， etc. It is expected to be excellent carriers of antitumor drugs. MSNs application in the field of cancer treatment has now become a hot research field of medicine. In this paper， the latest research about MSNs in antitumor drugs targeting delivery system from 2008 to 2015 is summarized， including the application of MSNs separately in antitumor d