亮丙瑞林与戈舍瑞林对卵巢子宫内膜异位症术后复发及妊娠成功率影响.docVIP

亮丙瑞林与戈舍瑞林对卵巢子宫内膜异位症术后复发及妊娠成功率的影响 　　[摘要]目的 探?亮丙瑞林与戈舍瑞林对卵巢内膜异位症腹腔镜手术患者的术后复发率及治疗后妊娠成功率的影响。方法 回顾性分析2012年6月～2016年6月我院收治的育龄期并有生育要求行保守性手术治疗的71例卵巢子宫内膜异位症患者的资料，按照术后是否用药及用药种类分为三组，分别为未用药组（NON组，26例）、国产亮丙瑞林组（LEU组，24例，3.75 mg/28 d）、戈舍瑞林组（GOS组，21例，3.6 mg/28 d）。比较三组患者的临床有效率、复发率、成功受孕率、痛经缓解率、不良反应发生率。结果 NON组患者的临床有效率（61.5%）显著低于LEU组（70.8%）和GOS组（76.2%），差异有统计学意义（P0.05）。NON组患者成功受孕率（38.5%）、痛经缓解率（65.3 %）显著低于LEU组（70.8%，75.0%）和GOS组（76.2%，71.4%），差异有统计学意义（P0.05）。结论 对于卵巢子宫内膜异位症患者，保守性手术治疗后辅助GnRH-a药物治疗，可以有效地提高临床有效率及治疗后成功受孕率，降低复发率及治疗后痛经发生率，减少不良反应发生率，但亮丙瑞林和戈舍瑞林的作用无明显差异。 　　[关键词]卵巢子宫内膜异位症；促性腺激素释放激素激动剂；亮丙瑞林；戈舍瑞林 　　[中图分类号] R711.71 [文献标识码] A [文章编号] 1674-4721（2017）10（c）-0098-04 　　Effect of Leuprorelin and Goserelin on recurrence and pregnancy rates after ovarian endometriosis operation 　　FAN Lian-yun WAN Gui-ping▲ 　　Department of Obstetrics and Gynecology，Chinese and Western Medicine Combined Hospital of Jiangsu Province，Nanjing 210028，China 　　[Abstract] Objective To investigate the effect of Leuprorelin and Goserelin on recurrence and pregnancy rates after ovarian endometriosis laparoscopic surgery.Methods A total of 71 cases female patients with ovarian endometriosis，fertility intention and received conservative operation who treated in our hospital from June 2012 to June 2016 were retrospectively analyzed.According to the medication they received，patients were divided into three groups，including group NON （no medication，n=26），group LEU （Leuprorelin，3.75 mg/28d，n=24），and group GOS （Goserelin，3.6 mg/28d，n=21）.The clinical efficacy，recurrence rates after treatment，rates of successful pregnancy，alleviated rates of dysmenorrhea and incidence of adverse reaction of each group were compared.Results The clinical efficiency of group NON （61.5%） was significantly lower than group LEU （70.8%） and group GOS （76.2%），and the differences were statistically significant （P0.05）.The successful pregnancy rate （38.5%），dysmenorrhea alleviated rate （65.3%） of group NON were significantly lower than that of group LEU