亮蓝嵴联合血清胃蛋白酶原对胃粘膜肠上皮化生诊断价值.docVIP

亮蓝嵴联合血清胃蛋白酶原对胃粘膜肠上皮化生的诊断价值 　　[摘要] 目的 探?亮蓝嵴（light blue crest LBC）联合血清胃蛋白酶原（serum pepsinogen sPG）对胃粘膜肠上皮化生的诊断价值。方法 采用回顾性研究方法对2015年6月―2016年9月在该院门诊及住院已行NBI-ME检查的142例并确诊为慢性胃炎的患者进行检查，根据窄带成像放大内镜（narrow band imaging-magnifying endoscopy NBI-ME）检查是否观察到LBC及血清胃蛋白酶原I（serum pepsinogen I sPGI）是否下降，分为4组，分别为LBC（+）-sPG（+），LBC（+）-sPG（-），LBC（-）-sPG（+），LBC（-）-sPG（-）。以病理标准评估上述4组肠上皮化生的活检预测率，比较LBC联合sPG与单独用LBC预测肠上皮化生阳性率的差异性。结果 经LBC（+）-sPG（+）检出胃粘膜肠上皮化生率显著高于LBC（+）-sPG（-）组（96.36% vs 31.25%，P0.05）。结论 亮蓝嵴联合血清胃蛋白酶原可提高胃粘膜肠上皮化生的检出率，可作为一种联合检查手段向临床推广。 　　[关键词] 亮蓝嵴；血清胃蛋白酶原；肠上皮化生 　　[中图分类号] R4 [文献标识码] A [文章编号] 1674-0742（2017）05（a）-0012-04 　　[Abstract] Objective To access light blue crest（LBC） combined with serum pepsinogen（sPG） diagnosis value in gastric mucosa intestinal metaplasia.Methods With retrospective study we analyse the 142 cases of patients diagnosed with chronic gastritis by NBI-ME from June 2015 to September 2016 in our hospital，who were in the outpatient and hospitalized， according to the narrow band imaging with magnifying endoscopy （NBI-ME） to check whether the observed LBC and serum pepsinogen I （serum pepsinogen I sPGI） has declined，divided into four groups，separately marked as LBC（+）-sPG（+），LBC（+）-sPG（-），LBC（-）-sPG（+），LBC（-）-sPG（-）.To estimate the biopsy predictive rate of intestinal metaplasia in the four groups by pathological standard，we compare the differences between LBC combined with sPG and LBC alone which are predictive the positive rate of intestinal metaplasia.Results The biopsy rate of gastric mucosa intestinal metaplasia for the group of LBC（+）-sPG（+） is significant higher than the the group of LBC（+）-sPG（-）（96.36% vs 31.25%，P0.05）.Conclusion Light blue crest combined with serum pepsinogen can improve the detection rates of gastric intestinal metaplasia，and can be used as a joint test for spreading clinic. 　　[Key words] Light blue crest；Serum pepsinogen；Intestinal dysplasia 　　在全世界，胃癌已成为发病率居第五和致死率居第三的常见恶性肿瘤[1]。胃粘膜肠上皮化生是胃癌进展的重要环节，更有Shimoyama等[2]研究认为，在日本肠上皮化生是肠型胃癌发病的唯