cMPDs患者JAK2+V617F点突变和ETS2+mRNA表达及其相关性的研究.pdf

英文摘要 andmutation was t-test．Theresults negativegroupanalyzedby wereshownas mean±SD(X±s1． Results： 1 TheJAK2V617F mutationwasdetectedin44 point BCR／ABL MPD 23／26(88．46％) negative patients．including and thesomaticJAK2 patients1／1(100％)CNLpatient．While V617Fmutationwasnotdetectedeitherinthe20CML patients， 10AL or the15healthvolunteers． patients 2Therelative levelofETS2mRNAinBCR／ABL expression cMPDs i,alue rate negative group(mean0．2876，positive 8 inCML value0．41 rate 1．96％)，or group(mean33，positive inAL value rate 85．0％)，or group(mean0．5320，positive 80．0％1is thanthatinhealth statisticallysignificanthigher volunteer value rate 46．7％)． group(mean0．106，positive PO．05． 3Therelative levelofETS2mRNAin expression JAK2V617F mutation value rate positivegroup(mean 86．0％) 0．323，positive is thanthatin statisticallysignificant higher negativegroup value rate (mean 72．2％)．P=0．022． 0．203，positive 4The ofclinical comparison characteristics：The