利拉鲁肽联合二甲双胍治疗多囊卵巢综合征对妊娠期糖尿病发病率影响.docVIP

利拉鲁肽联合二甲双胍治疗多囊卵巢综合征对妊娠期糖尿病发病率影响 　　[摘要]目的 ?^察利拉鲁肽联合二甲双胍治疗对多囊卵巢综合征（PCOS）妇女妊娠期糖尿病（GDM）发病率的影响。方法 选取2014年10月～2017年4月就诊于辽宁省人民医院内分泌科的诊断为PCOS的60例初次妊娠妇女，按照妊娠前是否使用利拉鲁肽治疗分为试验组（n=21）和对照组（n=39）。试验组为利拉鲁肽联合二甲双胍治疗超过6个月的妇女，并且妊娠后继续二甲双胍治疗。对照组为单纯口服二甲双胍治疗的PCOS妊娠妇女，妊娠期间未继续二甲双胍治疗。所有研究对象在妊娠期间进行口服葡萄糖耐量试验（OGTT），观察两组的GDM发病率、剖宫产率、早产率和体重变化情况。结果 试验组在妊娠前的减重率高于对照组，差异有统计学意义（P0.05）。试验组的GDM发病率低于对照组，差异有统计学意义（P0.05）；试验组妊娠第24、32、36周的体重分别低于对照组，差异有统计学意义（P0.05）。结论 利拉鲁肽联合二甲双胍治疗可预防性降低PCOS妇女GDM发病率。 　　[关键词]妊娠期糖尿病；多囊卵巢综合征；二甲双胍；利拉鲁肽 　　[中图分类号] R714.256 [文献标识码] A [文章编号] 1674-4721（2018）4（a）-0019-04 　　Influence of Liraglutide combined with Metformin in the treatment of polycystic ovary syndrome on the morbidity of gestational diabetes mellitus 　　HU Xiao-na 　　The First Department of Endocrinology，People′s Hospital of China Medical University People′s Hospital of Liaoning Province，Shenyang 110015，China 　　[Abstract]Objective To observe the influence of Liraglutide combined with Metformin treating polycystic ovary syndrome （PCOS） on the morbidity of gestational diabetes mellitus （GDM）.Methods Sixty -pregnancy women diagnosed with PCOS who visited the Department of Endocrinology in our hospital from October 2014 to April 2017 were enrolled and divided into the experimental group （n=21） and the control group （n=39） based on whether Liraglutide was used or not before pregnancy.In the experimental group，participants were treated with Liraglutide combined with Metformin for more than 6 months before pregnancy and continued with Metformin after pregnancy.In the control group，oral administration of Metformin alone was adopted for these PCOS women，and did not continue Metformin treatment during pregnancy.All subjects were provided with oral glucose tolerance test （OGTT） during pregnancy.The incidence of GDM，cesarean section rate，premature birth rate and weight change were observed in the two groups.Results The weight loss rate of the experimental group before pregnancy was higher than that of the control group，with sign