右美托咪定对老年患者胸科手术麻醉苏醒期不良反应预防作用.docVIP

右美托咪定对老年患者胸科手术麻醉苏醒期不良反应预防作用 　　[摘要] 目的 探讨右美托咪定（盐酸右美托咪定注射液）对老年患者胸科手术麻醉苏醒期不良反应的预防作用。 方法 回顾性分析该院麻醉科自2013年1月―2014年12月接受治疗且符合研究标准的86例老年胸科手术患者的临床资料，把86例患者随机分为实验组和对照组两组进行比对分析，每组43例患者。实验组患者用右美托咪定，对照组患者用生理盐水做对照。记录两组患者苏醒期间咳嗽，不自主运动等不良反应的发生情况，患者的疼痛情况（VAS）以及不同时间点MAP，HR的数值。 结果 两组患者有明显差异，患者拔管5 min，对照组患者的MAP、HR值相比于实验组患者有明显的升高，差异有统计学意义（P0.05）。 结论 右美托咪定对老年患者胸科手术麻醉苏醒期的不良反应有极好的预防作用，值得在今后的临床实践中广泛的推广和应用。 　　[关键词] 右美托咪定；老年胸科手术患者麻醉；不良反应的预防 　　[中图分类号] R61 [文献标识码] A [文章编号] 1674-0742（2016）02（b）-0035-03 　　[Abstract] Objective To investigate the effect of Dexmedetomidine （Dexmedetomidine Hydrochloride Injection） on the prevention of the incidence of adverse reactions in elderly patients with thoracic surgery during the emergence from anesthesia. Methods A retrospective analysis was conducted on the clinical data of 86 elderly patients undergoing thoracic surgery and meeting the criteria of the study admitted in Department of Anesthesiology of our hospital from January 2013 to December 2014. For the comparative analysis， the patients were randomly divided into the experimental group and the control group with 43 patients in each. The experimental group were treated with Dexmedetomidine， the control group were treated with saline for comparison. The incidence of cough， involuntary movements and other adverse reactions， the pain degree （VAS） and the values of MAP and HR at different time points of the two groups were recorded. Results The values of MAP and HR were much higher in the control group than those in the experimental group at 5 min after the extubation with statistically significant differences（P0.05）. Compared with the control group， the severity and frequency of cough， incidence of involuntary movements were much lower in the experimental group. The VAS scores were also lower in the experimental group than those in the control group. The time of extubation was more or less the same in both groups with no statistically significant difference. Conclusion Dexmedetomidine has good effect