原发性开角型青光眼药物治疗中远期疗效评价.docVIP

原发性开角型青光眼药物治疗中远期疗效评价 　　摘要：目的 评价原发性开角型青光眼（POAG）采用药物治疗的中、远期疗效及安全性。方法 随机抽选2013年1月～2015年2月我院眼科门诊收治的58例POAG患者，随诊时间在1～3年，全面评估病情后应用拉坦前列素滴眼液进行治疗，治疗后3个月、6个月、1年、3年分别行视力检查、眼压检查及视野检查，复查眼压并与治??前眼压对比，观察用药后有无出现全身或局部不良反应。结果 本组患者用药后半年、1年与3个月平均眼压对比存在明显差异（P0.05），有7例（12.10%）患者结膜充血但症状轻微减少药量或停药后症状消失，未影响治疗及随访。结论 药物治疗能够在短期内降低患者眼压，中止眼压过高对视神经造成的损害，而且安全性较高，但是从长期来看药物治疗并不能有效控制眼压，仍需及时进行手术治疗。 　　关键词：原发性开角型青光眼；药物治疗；拉坦前列素滴眼液；疗效指标 　　Abstract：Objective To evaluate the primary open-angle glaucoma（POAG）with drug treatment，the long-term efficacy and safety.Methods 58 cases of POAG were randomly selected in January 2013～2015 year in February in our hospital outpatient department，the follow-up time in 1～3 years，a comprehensive assessment of the application of Latanoprost Eye Drops condition after treatment，3 months after treatment，the first half of the year，1 years and 3 years respectively for visual acuity，intraocular pressure and visual field examination，IOP and IOP were compared with before treatment， after treatment with no local or systemic adverse reactions.Results This group of patients after six months，there is significant difference among the 1 years and 3 months the average intraocular pressure（P0.05），7 cases （12.10%）patients with mild symptoms of conjunctival congestion but reduce the dose or withdrawal symptoms disappeared after.No effect of treatment and follow-up.Conclusion Drug therapy can reduce the intraocular pressure of the patients in the short term，to suspend the high intraocular pressure of optic nerve damage，and high safety， but in the long term drug treatment can not effectively control the intraocular pressure， still need timely surgical treatment. 　　Key words：Primary open-angle glaucoma；Drug therapy；Latanoprost Eye Drops；Curative effect index 　　原发性开角型青光眼（primary open-angle glaucoma，POAG）是眼科常见青光眼疾病，约占所有青光眼的60%甚至更高，常常累及双眼，引发视功能损害，急性期可严重损害中心视力，预后较差[1]。药物治疗仍然是当前最主要的治疗方法，尤其是早期患者给予适当的药物治疗可最大限度地避免隐蔽性视功能损害。药物治疗一般以局部低浓度开始，根据治疗情况随时调整浓度或附加其他药物，只有在药物治疗不能有效控制视野损害进展时才考虑手术治疗[2-3]。为进一步探讨POA