右美托咪定经鼻给药在小儿麻醉中应用.docVIP

右美托咪定经鼻给药在小儿麻醉中应用 　　[摘要] 目的 研究分析右美托咪定术前经鼻给药在外科手术麻醉中的应用价值。 方法 选择2014年1月～6月我院收治的拟行外科手术治疗的小儿患者86例，随机分成研究组与对照组，每组各43例。研究组经鼻给药右美托咪定 1 μg/kg实施麻醉诱导，对照组则采用咪达唑仑0.1 mg/kg 经鼻给药实施麻醉诱导。比较两组麻醉诱导效果。 结果 两组患儿经鼻给药后T1（10 min）、T2（20 min）、T3（30 min）等时间点HR、SpO2、RR的差异比较有统计学意义（P0.05），两组HR、SpO2、RR等指标随着时间而降低。与对照组比较，研究组患儿的镇静满意度明显升高（P0.05）。结论 与咪达唑仑比较，右美托咪定经鼻给药用于小儿外科手术麻醉中可以收到较好的镇静效果，诱导时间短、面罩接受率高、术后躁动发生率低，对患儿苏醒时间不会延长，镇静满意度高。 　　[关键词] 右美托咪定； 咪达唑仑；小儿手术；麻醉诱导；术后躁动 　　[中图分类号] R614 [文献标识码] B [文章编号] 1673-9701（2015）04-0117-03 　　[Abstract] Objective To investigate and analyze the value of dexmedetomidine preoperative administration by nasal method in surgical anesthesia. Methods 86 pediatric patients who were implemented for surgical treatment from January to June in 2014 in our hospital were randomly divided into study group and control group， and each group was 43 cases. The study group was given 1 μg/kg dexmedetomidine and the control group was given 0.1 mg/kg midazolam both by nasal method to implement anesthesia induction. And the anesthesia induction effects were compared. Results At some points of time such as T1 （10 min）， T2 （20 min）， T3 （30 min） after the administration by nasal method in the children in the two groups， the differences of HR， SpO2， RR were statistically significant （P0.05）， and indicators of the two groups such as HR， SpO2， RR reduced with the passage of time. Satisfaction of sedation and mask acceptance rate of the children in study group significantly increased （P0.05）. Conclusion The comparison of midazolam and dexmedetomidine shows that dexmedetomidine administration by nasal method applied in anesthesia in pediatric surgery has better sedative effect， shorter induction time， higher mask acceptance rate， lower postoperative restlessness incidence， less recovery time of children and higher satisfaction of sedation. 　　[Key words] Dexmedetomidine； Midazolam； Pediatric operation； Anesthesia induction； Postoperative restlessness 　　小儿群体比较特殊，对手术治疗比较恐惧，很难配合医生进行手术治疗[1]。为此，不宜将小儿直