叶酸对慢性心力衰竭患者血清同型半胱氨酸和VEGFTNF影响.docVIP

叶酸对慢性心力衰竭患者血清同型半胱氨酸和VEGFTNF影响 　　[摘要] 目的 探?叶酸对慢性心力衰竭患者血清同型半胱氨酸和VEGF、TNF的影响。方法 选取2014年7月～ 2016年7月在本院住院治疗的慢性心力衰竭患者118例，根据数字表法随即将患者分为对照组和观察组，每组59例，对照组患者均给予常规治疗，观察组在对照组的基础上加叶酸，维生素B12，治疗6个月后，比较两组患者血清中的同型半胱氨酸（Hcy）、血管内皮生长因子（VEGF）、肿瘤坏死因子（TNF-α）的浓度变化，以及心功能改善情况。结果 治疗后，对照组患者的Hcy、VEGF、TNF-α分别为（17.5±3.1）μmol/L、 　　（157.3±16.1）pg/mL、（14.7±3.5）pg/mL显著低于治疗前，观察组患者的Hcy、VEGF、TNF-α分别为（13.6±3.5）μmol/L、（116.4±14.2）pg/mL、（9.6±3.2）pg/mL显著低于治疗前，观察组患者Hcy、VEGF、TNF-α含量显著低于对照组，且差异均具有统计学意义；治疗后，观察组患者的LVEDD 、IVST、E/A比值、LVEF分别为（57.1±3.2）mm、（9.4±1.6）mm、（1.4±0.3）、（50.2±3.6）%均显著高于对照组LVEDD （52.3±3.9mm、IVST（8.0±1.3）mm、E/A比值（0.9±0.2）、LVEF（45.7±3.5）%，且差异具有统计学意义。结论 叶酸可以有效的降低慢性心里衰竭患者的Hcy、VEGF、TNF-α的含量，改善心功能，值得临床推广。 　　[关键词] 叶酸；慢性心力衰竭；同型半胱氨酸；VEGF；TNF 　　[中图分类号] R541.6 [文献标识码] A [文章编号] 2095-0616（2017）15-217-04 　　[Abstract] Objective To investigate the effect of folic acid on serum homocysteine and VEGF， TNF in patients with chronic heart failure. Methods Selected 118 patients with chronic heart failure treated in our hospital from July 2014 to July 2016 were divided into control group and study group according to the number table， 59 cases in each group. The control group was given conventional treatment， and the observation group treated with folic acid and vitamin B12 based on the treatment of the control group. After 6 months of treatment， homocysteine in serum（Hcy）， vascular endothelial growth factor（VEGF）， tumor necrosis factor α（TNF-α） changes and improvement of heart function between two groups were compared. Results After treatment， the levels of Hcy， VEGF and TNF-αin the control group were （17.5±3.1）μmol /L，（157.3±16.1）pg/mL， （14.7±3.5） pg/mL respectively， which were lower than before treatment significantly. The levels of Hcy， VEGF and TNF-α in the observation group were （13.6±3.5）μmol/L， （116.4±14.2） pg/mL，（9.6±3.2） pg/mL， which were significantly lower than before treatment. The levels of Hcy， VEGF and TNF-α in the observation group were significantly lower than those in the control group， and t