吡格列酮西格列汀与二甲双胍联合治疗血糖控制不佳2型糖尿病肥胖患者疗效观察.docVIP

吡格列酮西格列汀与二甲双胍联合治疗血糖控制不佳2型糖尿病肥胖患者疗效观察 　　[摘要]目的 探究吡格列酮、西格列汀与二甲双胍联合治疗血糖控制不佳的2型糖尿病肥胖患者的临床效果。方法 选取我院2013年6月～2014年6月血糖控制不佳的2型糖尿病肥胖患者100例，根据随机数字表法将其分为研究组、对照组，每组50例，研究组进行吡格列酮、西格列汀与二甲双胍联合疗法，对照组仅进行吡格列酮与二甲双胍疗法，两组均治疗3个月，比较两组患者治疗前后糖化血红蛋白（HbA1c）、餐后2 h血糖（2 hPG）、空腹血糖（FPG）、体质量指数（BMI）；比较两组患者治疗后的空腹胰岛素（FINS）、空腹C肽（CP0）、餐后2 h胰岛素（2 h/INS）、餐后2 h C肽（CP2）水平；比较两组的不良反应发生率。结果 治疗后，两组患者的HbA1c、2 hPG、FPG均有改善，研究组治疗后的HbA1c、2 hPG、FPG、BMI显著优于对照组（P0.05）。结论 对血糖控制不佳的2型糖尿病肥胖患者进行吡格列酮、西格列汀与二甲双胍联合疗法，可显著控制血糖水平，降低机体胰岛素抵抗，控制体重，临床效果确切，值得临床推广。 　　[关键词]2型糖尿病肥胖；吡格列酮；西格列汀；二甲双胍 　　[中图分类号]R587.1 [文献标识码]A [文章编号]1674-4721（2016）06（b）-0038-03 　　Clinical effects observation of pioglitazone，sitagliptin and metformin combination in treating type 2 diabetes and obesity patients with poor glycemic control 　　XU Yu-feng LIANG Yong-qian LI Ying 　　Department of Endocrinology，the First People′s Hospital in Shunde District，Foshan City，Guangdong Province，Foshan 528300，China 　　[Abstract]Objective To explore the clinical effects of pioglitazone，sitagliptin combined with metformin in treating type 2 diabetes and obesity patients with poor glycemic control.Methods 100 type 2 diabetes and obesity patients with poor glycemic control from June 2013 to June 2014 of our hospital were selected.Patients were divided into study group and control group according to random number table，and each group was 50 cases.Patients in study group were used pioglitazone，sitagliptin and metformin.Patients in control group were only used pioglitazone and metformin.All patients in two groups were treated for 3 months.The clinical index of glycated glycosylated hemoglobin（HbA1c），2 hour postprandial blood glucose（2 hPG），fasting blood glucose（FPG） and body mass index（BMI） in two groups before and after treatment were compared.After treatment，the level of fasting insulin（FINS），fasting c-peptide（CP0），postprandial 2 h insulin（2 h/INS） and postprandial 2 h C peptide（CP2） in two groups were compared.The rate of adverse effects in two groups were compared.Results A