国产注射用醋酸亮丙瑞林在子宫内膜异位症术后应用研究.docVIP

国产注射用醋酸亮丙瑞林在子宫内膜异位症术后应用研究 　　? 　　[摘要] 目的 评估国产注射用醋酸亮丙瑞林预防子宫内膜异位症术后复发的疗效和安全性。 方法 将150例年龄在29～49岁的术后进行药物治疗的子宫内膜异位症患者随机分成3组：酸酸亮丙瑞林微球组、口服避孕药达英35组、中成药桂枝茯苓胶囊组。比较患者在药物治疗后3个月和6个月时痛经的复发率、子宫内膜异位肿块的复发率、性激素的水平变化、CA125水平和药物副反应率。 结果 各组的生殖激素水平和CA125水平均有下降，醋酸亮丙瑞林微球组下降最显著。醋酸亮丙瑞林微球组复发率最低，不良反应率在3组无明显差异。 结论 与口服避孕药达英35和中成药相比，注射用醋酸亮丙瑞林微球对预防子宫内膜异位症的术后复发具有价格便宜，复发率低，药物不良反应率低等优点。 　　[关键词] 注射用醋酸亮丙瑞林微球；口服避孕药；中成药；术后复发 　　[中图分类号] R711.71 [文献标识码] A [文章编号] 2095-0616（2014）10-56-04 　　[Abstract] Objective To evaluate the efficacy and safety of domestic leuprolide acetate injection in preventing postoperative recurrence of endometriosis. Methods 150 endometriosis patients aged 29 years to 49 years who received postoperative drug treatment were randomly divided into 3 groups， namely the leuprolide acetate microsphere group， the oral contraceptive Diane-35 group and the Chinese patent medicine Guizhi Fuling capsule group. The recurrence rates of dysmenorrhea， recurrence rates of endometriosis lump， changes of sex hormone levels， CA125 levels and adverse drug reaction rates of the patients after 3 and 6 months of drug treatment were compared. Results The reproductive hormone levels and CA125 levels of all groups dropped and the leuprolide acetate microsphere group dropped most significantly. The leuprolide acetate microsphere group had the lowest recurrence rate and the adverse reaction rates were not significantly different among the 3 groups. Conclusion Compared to oral contraceptive Diane-35 and Chinese patent medicine， leuprolide acetate microsphere injection has the advantages of cheap price， low recurrence rate and low adverse drug reaction rate in preventing postoperative recurrence of endometriosis. 　　[Key words] Leuprolide acetate microsphere injection； Oral contraceptives； Chinese medicine； Postoperative recurrence 　　在非内异症的妇科的经腹手术中，子宫内膜异位症的发生率可达5%～15%；而因不孕症进行腹腔镜检查的患者，12%～48%的患者可发现有此疾病。目前，手术治疗是子宫内膜异位症首选的治疗方法[1]。但事实上保守性手术又难以完全清除内异症病灶，因此术后内异症极容易复发。部分内异症患者甚至在术后的几个月内即可复发，既增加了患者的痛苦，又为进一步的诊治带来困难。因此