唾液乳杆菌嗜酸乳杆菌及植物乳杆菌三联活菌制剂联合三联疗法根除幽门螺杆菌临床研究.docVIP

唾液乳杆菌嗜酸乳杆菌及植物乳杆菌三联活菌制剂联合三联疗法根除幽门螺杆菌临床研究 　　【摘要】 目的：探?唾液乳杆菌、嗜酸乳杆菌及植物乳杆菌三联活菌制剂联合三联疗法根除幽门螺杆菌的临床效果。方法：按照入院顺序抽签后随机将180例Hp阳性慢性胃炎或消化性溃疡患者分为益生菌组和对照组，每组各90例。对照组患者给予常规三联疗法治疗，益生菌组患者在此基础上加用益生菌治疗，比较两组患者治疗8周后临床疗效，Hp根除效果及治疗过程中不良反应情况。结果：益生菌组患者治疗总有效率显著高于对照组（94.44% vs 83.33%），比较差异有统计学意义（P0.05）；益生菌组患者Hp根除率显著高于对照组（93.33% vs 81.11%），比较差异有统计学意义（P0.05）；益生菌组患者不良反应发生率显著低于对照组（14.44% vs 35.56%），比较差异有统计学意义（P0.05）。结论：唾液乳杆菌、嗜酸乳杆菌及植物乳杆菌三联活菌制剂联合三联疗法根除幽门螺杆菌效果好，不良反应少，可作为优选治疗方案。 　　【关键词】 唾液乳杆菌； 嗜酸乳杆菌； 植物乳杆菌； 三联疗法； 幽门螺杆菌 　　Clinical Study of Lactobacillus Salivarius，Lactobacillus Acidophilus and Lactobacillus Triple Viable Capsules Combined with Triple Therapy for Helicobacter Pylori Eradication/YUAN Kai-tao，LIU Guan-huan，ZUO Ji-dong.//Medical Innovation of China，2017，14（10）：036-039 　　【Abstract】 Objective：To investigate the clinical effect of Lactobacillus salivarius， Lactobacillus acidophilus and Lactobacillus triple viable capsules combined with triple therapy for Helicobacter pylori eradication. Method： According to the order of admission after the draw randomly 180 cases of Hp positive chronic gastritis or peptic ulcer patients were divided into probiotics group and control group，90 cases in each group.The control group was given routine triple therapy，probiotics group based on the control group was given probiotics in the treatment，after 8 weeks the clinical curative effect，Hp eradication effect and the adverse reactions in the course treatment of two groups were compared.Result：The total efficiency in probiotics group was significantly higher than that of the control group（94.44% vs 83.33%），the difference was statistically significant（P0.05）；the Hp eradication rate in probiotics group was significantly higher than that of the control group（93.33% vs 81.11%），the difference was statistically significant（P0.05）； the adverse reaction rate in the probiotics group was significantly lower than that of control group（14.44% vs 35.56%），the difference was statistically significant（P0.05）.Conclusion：Lacto