国产氯吡格雷联合前列地尔丹红注射液治疗椎基底动脉供血不足所致眩晕临床疗效观察.docVIP

国产氯吡格雷联合前列地尔丹红注射液治疗椎基底动脉供血不足所致眩晕临床疗效观察 　　【摘要】 目的：评价国产氯吡格雷联合前列地尔、丹红注射液治疗椎基底动脉供血不足（Vertebral-basilar artery insufficiency，VBI）所致眩晕的有效性与安全性。方法：84例VBI所致眩晕患者，按照随机列表分为治疗组44例，给予前列地尔、丹红注射液联合口服氯吡格雷治疗。对照组40例，仅给予前列地尔、丹红注射液联合治疗。连续治疗7～14 d，评估患者的起效时间、临床疗效。采用TCD检测椎基底动脉血流速度并检测患者的血液流变学指标。结果：治疗组在0～2 h起效患者比例47.7%及0～6 h起效患者比例88.6%显著高于对照组的25.0%、55.0%。临床疗效方面，治疗组显效率65.9%、总有效率95.4%均明显高于对照组的42.5%、77.5%，两组比较差异有统计学意义（P0.05）。采用TCD检测椎基底动脉血流速度发现，治疗组左侧椎动脉的血流速度（44.3±4.2）cm/s、右侧椎动脉（44.2±9.7）cm/s、基底动脉（45.7±10.8）cm/s改善优于对照组的（41.5±4.7）cm/s、（42.4±9.4）cm/s、（43.6±8.4）cm/s，两组比较差异有统计学意义（P0.05）。血液流变学检测显示，治疗组治疗后血浆比黏度、还原高切、还原低切、血小板聚集率改善优于对照组，两组比较差异有统计学意义（P0.05）。另外治疗组21 d内0例发生TIA或脑卒中，对照组3例发生TIA，1例进展为脑卒中，两组比较差异有统计学意义（字2=4.620，P=0.032）。治疗过程中两组均未见明显的不良反应。结论：国产氯吡格雷联合前列地尔、丹红注射液可显著改善椎基底动脉供血不足所致眩晕，治疗过程极少发生不良反应。 　　【关键词】 眩晕； 氯吡格雷； 丹红注射液； 前列地尔 　　中图分类号 R543 文献标识码 A 文章编号 1674-6805（2015）9-0001-03 　　The Clinical Curative Effect Observation of Domestic Clopidogrel，Alprostadil and Danhong Injection in the Treatment of Vertigo Caused by VBI/LU Ming，LIU Yu-xi，ZHU Zi-qiao，et al.//Chinese and Foreign Medical Research，2015，13（9）：1-3 　　【Abstract】 Objective：To evaluate the efficacy and safety of domestic Clopidogrel，Alprostadil and Danhong Injection in the treatment of vertigo caused by vertebral-basilar artery insufficiency（VBI）.Method：84 cases of vertigo patients caused by VBI were randomly divided into the treatment group（n=44，treated with domestic Clopidogrel，Alprostadil and Danhong Injection） and the control group（n=40，treated with Alprostadil and Danhong Injection）.Then the clinical onset time and clinical efficacy，basilar artery blood flow velocity and hemorheology of patients after 7-14 d continuous treatment were assessed.Result：The clinical onset patients of 0-2 h in the treatment group was 47.7%，0-6 h was 88.6%，they were higher than the 25.0% and 55.0% of the control group，the efficiency and total efficiency were 65.9% and 95.4% in the treatment group，they were higher than the 42.5% and 77.5% of the control group，th