基于多元统计非酒精性脂肪性肝病中医病机研究.docVIP

基于多元统计非酒精性脂肪性肝病中医病机研究 　　摘要：目的 探讨非酒精性脂肪性肝病（NAFLD）中医病机规律，为临床辨证论治提供依据。方法 采用横断面研究方法，利用NAFLD中?t四诊临床观察表，对患者资料进行采集。采用因子分析、奇异值分解方法，研究四诊表现的内在因子特征，比较各种分析方法的差别。结果 因子分析采用了α因子解析法、主成分分析法、映像因子法，其中α因子解析法结果为最佳，前3个因子对数据解释率最高，分别为脾湿因子、肾虚因子和气虚因子，三者构成了NAFLD的基本病机因素；奇异值分解法得到的前3个奇异值分别为脾肾气虚、肝肾阴虚和气阴两虚，同样突出了脾肾两虚在NAFLD病机中的作用。结论 脾肾两虚在NAFLD病机组成中占有重要地位，从虚论治NAFLD具有重要的临床意义。 　　关键词：非酒精性脂肪性肝病；病机；因子分析；奇异值分解 　　DOI：10.3969/j.issn.1005-5304.2017.06.004 　　中图分类号：R259.755 文献标识码：A 文章编号：1005-5304（2017）06-0013-04 　　Abstract： Objective To explore the TCM pathogenesis regularity of nonalcoholic fatty liver disease （NAFLD）； To provide basis for clinical syndrome differentiation and treatment. Methods A cross-sectional study was used. The clinical observation form of NAFLD was used to collect the patient data. Factor analysis and singular value decomposition methods were used to study the internal factors of the four diagnostic characteristics. The differences between the various analytical methods were compared. Results Factor analysis used the α factor analysis method， the principal component method， and the image factor method. The results of α-factor analysis were the best. The first three factors had the highest explanatory rates of data， namely spleen-dampness factor， kidney deficiency factor and qi deficiency factor， which constituted the basic pathogenesis factor of NAFLD. The singular value decomposition method obtained 3 singular values， namely spleen and kidney qi deficiency， liver and kidney yin deficiency， and qi and yin deficiency， also highlighted the spleen and kidney deficiency in the pathogenesis of NAFLD. Conclusion Spleen-kidney deficiency plays an important role in the pathogenesis of NAFLD. Treatment based on deficiency for nonalcoholic fatty liver disease has great clinical significance. 　　Key words： nonalcoholic fatty liver disease； pathogenesis； factor analysis； singular value decomposition 　　非酒精性脂肪性肝病（nonalcoholic fatty liver disease，NAFLD）是一种无大量饮酒史，以有肝实质细胞脂肪变性和脂肪贮存为特征的临床病理综合征。近20年来