材料物理专业交联型三嵌段共聚物微胶囊pH响应的分子模拟研究毕业设计论文.docx

本 科 毕 业 设 计（论文） 题 目：交联型三嵌段共聚物微胶囊pH响应的分子模拟研究 学生姓名： 学 号： 专业班级：材料物理 指导教师： 2017年 6月18日 中国石油大学（华东）本科毕业设计(论文) 交联型三嵌段共聚物微胶囊pH响应的分子模拟研究 摘 要 本文通过耗散粒子动力学（DPD）方法，构建了由三嵌段共聚物PEG-b-PDEAEMA-b-PMMA、双环戊二烯（DCPD）和水组成的模型，在此基础上通过改变体系中三嵌段共聚物的浓度、链段长度和对三嵌段共聚物进行交联，来分析不同因素对DCPD装载与pH响应释放的影响。结果表明在疏水链段与填装药物相容性一般的情况下，必须使疏水链段较短，三嵌段共聚物浓度达到一定程度，才能实现DCPD的装载；并对三嵌段共聚物对DCPD的包裹和微胶囊的pH响应释放过程进行了分析；发现三嵌段共聚物包裹DCPD的微胶囊进行交联能有效的提高微胶囊的稳定性和完整性，并且对交联型微胶囊进行pH响应不会影响DCPD的释放。 关键词：耗散粒子动力学模拟；三嵌段共聚物微胶囊；交联；pH响应 Molecular simulation of pH response of crosslinked-triblock copolymer microcapsules Abstract This paper constructed a model by triblock copolymer PEG - b - PDEAEMA - b - PMMA, DCPD and water based on the dissipative particle dynamics (DPD) method. On this basis, by changing the system of triblock copolymer concentration, chain length and crosslink of the triblock copolymer to analyze the effect of different factors on DCPD loading and pH response release. The results showed that the hydrophobic segment must be shortened and the concentration of triblock copolymer must reach a certain extent in order to realize the loading of DCPD in the case of poor compatibility between the hydrophobic segment and the filled drug.Then, I analyzed the DCPD loading and the pH responsive release process of the three block copolymer. Microcapsules of triblock copolymer package DCPD crosslink can effectively improve the stability of the microcapsules and integrity, and the pH response type of crosslink microcapsules will not affect the release of DCPD. Keywords: Dissipative particle dynamics; Triblock copolymer microcapsules; Crosslink; pH-sensitive 目 录 TOC \o 1-3 \h \z \u HYPERLINK \l _Toc484036471 第1章 前言 PAGEREF _Toc484036471 \h 1 HYPERLINK \l _Toc484036472 1.1 嵌段共聚物 PAGEREF _Toc484036472 \h 1 HYPERLINK \l _Toc484036473 1.1.1 嵌段共聚物简介 PAGEREF _Toc484036473 \h 1 HYPERLINK \l _Toc484036474 1.1.2 嵌段共聚物的理论研究进展 PAGEREF _Toc484036474 \h 1 HYPERLINK \l _Toc484036475 1.2 微胶囊 PAGEREF _Toc484036475 \h 1 HYPERLINK \l _To